# p53-SOAT1 Axis: A Novel Target for Tumor Lipid Metabolism and Therapy **Authors:** Xi YU, Yuting XIAO, Bowen XU, Xinhui LI, Hongmei WANG, Dunqiang REN PMC · DOI: 10.3779/j.issn.1009-3419.2025.106.34 · Chinese Journal of Lung Cancer · 2025-12-20 ## TL;DR This paper explores how the p53 and SOAT1 proteins interact to influence cancer cell lipid metabolism and their potential as a new treatment target. ## Contribution The paper introduces the p53-SOAT1 axis as a novel target for cancer therapy by linking their roles in lipid metabolism. ## Key findings - p53 and SOAT1 are key regulators of lipid metabolism in cancer cells. - SOAT1 is overexpressed in various cancers and promotes tumor progression. - The p53-SOAT1 axis may offer new therapeutic strategies for cancer treatment. ## Abstract 癌症治疗是全球医学面临的重大挑战，其复杂的分子机制和药物耐药性是制约治疗效果的关键因素。异常的脂质代谢是肿瘤的重要特征之一，为肿瘤细胞的生长、增殖、迁移和侵袭提供代谢支持。肿瘤抑制因子p53蛋白和甾醇O-酰基转移酶1（sterol O-acyltransferase 1, SOAT1）在调控细胞脂质代谢中发挥重要作用，与多种肿瘤的发生发展及预后密切相关。p53蛋白通过多条信号通路调控肿瘤脂质代谢，而SOAT1作为胆固醇酯化的关键酶，在多种肿瘤中高水平表达并加速肿瘤进展进程。有研究表明p53蛋白与SOAT1可能存在功能性关联作用，协同调控肿瘤细胞的脂质稳态。本文综述了p53蛋白与SOAT1在肿瘤脂质代谢中的研究进展，重点阐述p53-SOAT1轴在肿瘤发生发展中的潜在作用机制，并展望其作为癌症治疗靶点的应用前景。 Summary of experimental and clinical evidence for targeting SOAT1 in cancer therapy ## Linked entities - **Genes:** TP53 (tumor protein p53) [NCBI Gene 7157], SOAT1 (sterol O-acyltransferase 1) [NCBI Gene 6646] - **Proteins:** TP53 (tumor protein p53), SOAT1 (sterol O-acyltransferase 1) ## Full-text entities - **Genes:** MVK (mevalonate kinase) [NCBI Gene 4598] {aka LRBP, MK, MVLK, POROK3}, SREBF2 (sterol regulatory element binding transcription factor 2) [NCBI Gene 6721] {aka SREBP-2, SREBP2, bHLHd2}, CD274 (CD274 molecule) [NCBI Gene 29126] {aka ADMIO5, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1}, LPIN1 (lipin 1) [NCBI Gene 23175] {aka PAP1}, SREBF1 (sterol regulatory element binding transcription factor 1) [NCBI Gene 6720] {aka HMD, IFAP2, SREBP1, bHLHd1}, PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) [NCBI Gene 5291] {aka P110BETA, PI3K, PI3KBETA, PIK3C1}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, PTK2B (protein tyrosine kinase 2 beta) [NCBI Gene 2185] {aka CADTK, CAKB, FADK2, FAK2, PKB, PTK}, MLYCD (malonyl-CoA decarboxylase) [NCBI Gene 23417] {aka MCD}, G6PD (glucose-6-phosphate dehydrogenase) [NCBI Gene 2539] {aka CNSHA1, G6PD1}, IFNG (interferon gamma) [NCBI Gene 3458] {aka IFG, IFI, IMD69}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, YAP1 (Yes1 associated transcriptional regulator) [NCBI Gene 10413] {aka COB1, YAP, YAP-1, YAP2, YAP65, YKI}, MVP (major vault protein) [NCBI Gene 9961] {aka LRP, VAULT1}, CREBBP (CREB binding lysine acetyltransferase) [NCBI Gene 1387] {aka CBP, KAT3A, MKHK1, RSTS, RSTS1}, VEGFC (vascular endothelial growth factor C) [NCBI Gene 7424] {aka Flt4-L, LMPH1D, LMPHM4, VRP}, LACTB (lactamase beta) [NCBI Gene 114294] {aka G24, MRPL56}, PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) [NCBI Gene 5295] {aka AGM7, GRB1, IMD36, p85, p85-ALPHA, p85alpha}, CPT1A (carnitine palmitoyltransferase 1A) [NCBI Gene 1374] {aka CPT I, CPT1, CPT1-L, CPTI-L, L-CPT1}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, FASN (fatty acid synthase) [NCBI Gene 2194] {aka FAS, OA-519, SDR27X1}, SOAT1 (sterol O-acyltransferase 1) [NCBI Gene 6646] {aka ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT}, CROT (carnitine O-octanoyltransferase) [NCBI Gene 54677] {aka COT}, PDCD1 (programmed cell death 1) [NCBI Gene 5133] {aka ADMIO4, AIMTBS, CD279, PD-1, PD1, SLEB2}, EP300 (EP300 lysine acetyltransferase) [NCBI Gene 2033] {aka KAT3B, MKHK2, RSTS2, p300}, SCD (stearoyl-CoA desaturase) [NCBI Gene 6319] {aka FADS5, MSTP008, SCD1, SCDOS, hSCD1} - **Diseases:** COAD (MESH:D029424), ACC (MESH:D004476), gastric cancer (MESH:D013274), adrenocortical carcinoma (MESH:D018268), colon adenocarcinoma (MESH:D003110), HCC (MESH:D006528), PDAC (MESH:C537768), pancreatic ductal adenocarcinoma (MESH:D021441), lung cancer (MESH:D008175), Cancer (MESH:D009369) - **Chemicals:** Lipid (MESH:D008055), dextran sulfate sodium (MESH:D016264), cholesterol (MESH:D002784), FA (MESH:D005492), Evacetrapib (MESH:C568301), ABT-737 (MESH:C501332), AOM (MESH:D001397), mevalonate (MESH:D008798), ApcMin (-), cholesterol esters (MESH:D002788), NADPH (MESH:D009249) - **Mutations:** R270C ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12972576/full.md ## Figures 2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12972576/full.md ## References 58 references — full list in the complete paper: https://tomesphere.com/paper/PMC12972576/full.md --- Source: https://tomesphere.com/paper/PMC12972576