# A case of autosomal dominant polycystic kidney disease with multiple bilateral spontaneous retroperitoneal hemorrhages

**Authors:** Masato Mizuta, Tatsuya Suwabe, Yuki Oba, Akinari Sekine, Masayuki Yamanouchi, Hiroki Mizuno, Eiko Hasegawa, Takehiko Wada, Makoto Fukuda, Motoaki Miyazono, Naoki Sawa, Yoshifumi Ubara

PMC · DOI: 10.1007/s13730-025-01079-x · CEN Case Reports · 2026-03-09

## TL;DR

A man with a kidney disease had multiple rare internal bleeding episodes, which were managed with a procedure that helped preserve kidney function.

## Contribution

This case highlights the effectiveness of renal transarterial embolization in managing rare retroperitoneal hemorrhages in ADPKD.

## Key findings

- The patient experienced multiple spontaneous retroperitoneal hemorrhages over eight years.
- Renal transarterial embolization was effective in controlling bleeding and preserving kidney function.
- The patient eventually required hemodialysis after the fourth bleeding episode.

## Abstract

We experienced a 45-year-old male with ADPKD who developed spontaneous retroperitoneal hemorrhages with hypertension in the right subcapsular renal space without trauma. After his condition worsened with conservative management, he was treated by renal transarterial embolization (TAE). Over the next eight years, he experienced bilateral bleeding at three different sites and underwent repeated endovascular treatment with renal TAE to stop the bleeding. After the fourth occurrence, the patient underwent hemodialysis. Although renal cysts and urinary tract bleeding occur frequently in ADPKD, retroperitoneal hemorrhage is rare; however, TAE is both effective and a good way to preserve renal function.

## Linked entities

- **Diseases:** autosomal dominant polycystic kidney disease (MONDO:0004691)

## Full-text entities

- **Genes:** ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}, REN (renin) [NCBI Gene 5972] {aka ADTKD4, HNFJ2, RTD}
- **Diseases:** thrombocytopenia (MESH:D013921), coagulation abnormalities (MESH:D001778), hypertension (MESH:D006973), anemia (MESH:D000740), cyst (MESH:D003560), renal cell carcinoma (MESH:D002292), arteriovenous fistula (MESH:D001164), urinary tract bleeding (MESH:D014570), ADPKD (MESH:D016891), ADPKD (MESH:D007690), systemic (MESH:D015619), renal enlargement (MESH:D006332), Page Kidney (MESH:D007674), abdominal tenderness (MESH:D000007), gastric discomfort (MESH:D013272), TAE (MESH:D004617), abdominal pain (MESH:D015746), aneurysm (MESH:D000783), renal function decline (MESH:D060825), renal failure (MESH:D051437), angiomyolipoma (MESH:D018207), retroperitoneal hemorrhage (MESH:D012186), pain (MESH:D010146), flank pain (MESH:D021501), Hematoma (MESH:D006406), Ehlers-Danlos syndrome (MESH:D004535), trauma (MESH:D014947), Cerebral aneurysm (MESH:D002532), polyarteritis nodosa (MESH:D010488), bladder tamponade (MESH:D001745), renal bleeding (MESH:D006030), genetic abnormality (MESH:D030342), nephritis (MESH:D009393), Bleeding (MESH:D006470)
- **Chemicals:** TAE (-), creatinine (MESH:D003404), amlodipine (MESH:D017311), aldosterone (MESH:D000450), Tolvaptan (MESH:D000077602), olmesartan (MESH:C437965)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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Source: https://tomesphere.com/paper/PMC12972201