# Coronary microvascular dysfunction in pregnancy: time to pay closer attention?

**Authors:** Eirini Beneki, Nikolaos Pyrpyris, Athanasios Sakalidis, Eirini Dri, Panayiotis Iliakis, Theodoros Mprotsis, Francesco Perone, Aggelos Papanikolaou, Konstantinos Aznaouridis, Kyriakos Dimitriadis, Konstantinos Tsioufis, Constantina Aggeli

PMC · DOI: 10.3389/fcvm.2026.1734077 · Frontiers in Cardiovascular Medicine · 2026-02-24

## TL;DR

This paper highlights the need for better understanding and management of coronary microvascular dysfunction in pregnant women.

## Contribution

The paper emphasizes the under-recognized issue of CMD during pregnancy and identifies key research gaps.

## Key findings

- CMD is increasingly recognized but poorly understood in pregnancy.
- CMD can arise from hypertensive disorders or pre-existing endothelial dysfunction.
- Current diagnostic and treatment approaches have significant limitations.

## Abstract

Coronary microvascular dysfunction (CMD) is increasingly recognized as a significant cardiovascular condition, particularly among women, yet its diagnosis and management during pregnancy remain poorly understood. CMD may arise de novo in the context of hypertensive disorders of pregnancy or represent an exacerbation of pre-existing endothelial dysfunction. This article views current evidence surrounding CMD in pregnancy, outlines the limitations of current diagnostic and treatment approaches, and highlights critical research gaps that must be addressed to improve outcomes in this vulnerable population.

## Full-text entities

- **Diseases:** endothelial dysfunction (MESH:D014652), CMD (MESH:D003327), cardiovascular condition (MESH:D002318), hypertensive disorders (MESH:D006973)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12971903/full.md

## References

34 references — full list in the complete paper: https://tomesphere.com/paper/PMC12971903/full.md

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Source: https://tomesphere.com/paper/PMC12971903