# Negative pressure wound therapy for perianal necrotizing fasciitis: case report and literature review

**Authors:** Hao Ma, Bei Zhang, Yahong Xue, Qingrui Liu, Jiahui Chen, Pei Wang, Hao Ge

PMC · DOI: 10.3389/fsurg.2026.1747876 · Frontiers in Surgery · 2026-02-24

## TL;DR

This case report shows that combining radical debridement with negative pressure wound therapy can improve outcomes in perianal necrotizing fasciitis.

## Contribution

The paper introduces a combined strategy of extended-incision debridement and early NPWT for treating PNF.

## Key findings

- Traditional interventions showed limited success in treating extensive PNF.
- The integrated strategy led to rapid infection control and faster wound healing.
- The approach may significantly improve PNF prognosis and overcome clinical challenges.

## Abstract

Perianal necrotizing fasciitis (PNF) is a life-threatening soft tissue infection with high mortality. Despite the established role of radical debridement, outcomes are often hindered by late diagnosis and suboptimal postoperative care. While negative pressure wound therapy (NPWT) promotes complex wound healing, its synergistic application with radical debridement in PNF requires further validation. We report a case of extensive PNF that demonstrated the limitations of traditional interventions. By utilizing an integrated strategy of extended-incision radical debridement and early NPWT, we achieved rapid infection control and accelerated wound healing. This case suggests that such a combined technical framework can overcome clinical challenges and significantly improve PNF prognosis.

## Full-text entities

- **Diseases:** PNF (MESH:D019115), infection (MESH:D007239)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12971884/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12971884/full.md

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Source: https://tomesphere.com/paper/PMC12971884