# Pancreatic intraductal papillary mucinous neoplasm with invasive carcinoma and uterine metastasis: a case report

**Authors:** Yingxue Guo, Yuan Wang, Fanghua Li, Yanxia Liu, Yixiu Han, Yingyun Zhang, Xiaolong Miao, Feifei Zhao

PMC · DOI: 10.3389/fonc.2025.1562588 · Frontiers in Oncology · 2026-02-24

## TL;DR

A rare case of pancreatic cancer with invasive carcinoma metastasizing to the uterus is reported, showing long-term survival after combined treatment.

## Contribution

Reports a rare uterine metastasis of IPMN with invasive carcinoma and successful treatment with surgery and chemotherapy.

## Key findings

- Metastasis to the uterus in IPMN with invasive carcinoma is uncommon.
- Combined debulking surgery and hyperthermic intraperitoneal chemotherapy improved survival in this case.
- Highlights the importance of multidisciplinary care for rare metastatic cases.

## Abstract

Intraductal papillary mucinous neoplasm (IPMN) with invasive carcinoma is a rare type of pancreatic cancer that has a better prognosis than classic pancreatic infiltrating ductal carcinoma. Most distant metastases occur in the lymph nodes, lungs, liver, and bones at advanced stages. We report a rare case of an IPMN with invasive carcinoma that metastasized to the uterus, resulting in long-term survival after debulking surgery combined with hyperthermic intraperitoneal chemotherapy on a systemic treatment basis. This rare case highlights the need for oncologists and gynecologists to be vigilant regarding these uncommon metastatic diseases and exercise caution in diagnosis. Comprehensive treatments, including debulking surgery, may improve survival.

## Linked entities

- **Diseases:** intraductal papillary mucinous neoplasm (MONDO:0004286), invasive carcinoma (MONDO:0040677), pancreatic cancer (MONDO:0005192)

## Full-text entities

- **Diseases:** IPMN (MESH:D000077779), invasive carcinoma (MESH:D009361), metastatic diseases (MESH:D000092182), metastases (MESH:D009362), pancreatic infiltrating ductal carcinoma (MESH:D021441), pancreatic cancer (MESH:D010190)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12971412/full.md

## References

26 references — full list in the complete paper: https://tomesphere.com/paper/PMC12971412/full.md

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Source: https://tomesphere.com/paper/PMC12971412