# Mapping dementia research in Indonesia: A scoping review of evidence, gaps, and future directions

**Authors:** Anna Tjin, Fasihah Irfani Fitri, Michael Maitimoe, Diany Syafitri, Shofia Mawaddah, Tung Le, Firda Aminy Ma’ruf, Sarah Bauermeister, Robert Stewart, Iracema Leroi, Asri Maharani, Damen Haile Mariam, Damen Haile Mariam

PMC · DOI: 10.1371/journal.pgph.0005444 · PLOS Global Public Health · 2026-03-09

## TL;DR

This review maps dementia research in Indonesia, highlighting recent growth, key themes, and areas needing improvement in dementia care and policy.

## Contribution

The study provides a comprehensive scoping review of dementia research in Indonesia, identifying gaps and future directions aligned with global health goals.

## Key findings

- Most dementia studies in Indonesia are recent and urban-focused, with limited geographical and methodological diversity.
- High psychosocial and financial burden is reported among dementia caregivers, especially women, with unmet support needs.
- Implementation of diagnostic tools and interventions is hindered by cost and workforce limitations.

## Abstract

Dementia, a syndrome that progressively impairs cognitive functions, is a growing global health challenge. Indonesia, the world’s fourth most populous country, faces a growing dementia burden compounded by stigma and inequities in prevention, diagnosis, and care. This scoping review aims to synthesise dementia research in Indonesia, identify gaps, and propose directions for future research. Following the Joanna Briggs Institute and PRISMA-ScR guidelines, a comprehensive search across eight databases (MEDLINE, Embase, CINAHL, Global Health, Web of Science, PubMed, PsycINFO, and GARUDA) were conducted to identify studies in English and Indonesian. 105 studies were included, with most (93.3%) studies published after 2016, aligning with Indonesia’s National Dementia Plan and the WHO Global Action Plan on Dementia. Studies were predominantly cross-sectional (73.3%) and concentrated in urban areas. When mapped against the WHO Global Action Plan on Dementia (2017–2025), studies clustered around seven key themes. Key risk factors examined included older age, low education, female sex, low socioeconomic status, smoking, hypertension, diabetes, and physical inactivity. Work on diagnosis, treatment, and care has expanded, particularly through validation of cognitive screening tools (e.g., MoCA-INA, BCSB-INA) and emerging use of neuroimaging and biomarkers, though implementation remains limited by cost and workforce capacity. Intervention studies are typically small-scale, short-term, and lack longitudinal evaluation. Findings consistently showed high psychosocial and financial burden, especially among female family carers, with unmet needs for training and emotional support. Finally, policy and systems-level research highlighted limited integration of dementia into primary healthcare, inadequate data infrastructure, and minimal progress in translating the 2016 National Dementia Plan into sustainable support systems. Dementia research in Indonesia has expanded, yet geographical and methodological gaps persist. Future priorities should include nationally representative studies, implementation research, and multisectoral collaborations to advance the WHO’s vision of dementia as a public health priority and strengthen preparedness for its ageing population.

## Linked entities

- **Diseases:** dementia (MONDO:0001627)

## Full-text entities

- **Genes:** BDNF (brain derived neurotrophic factor) [NCBI Gene 627] {aka ANON2, BULN2}, APOE (apolipoprotein E) [NCBI Gene 348] {aka AD2, APO-E, ApoE4, LDLCQ5, LPG}, IL1B (interleukin 1 beta) [NCBI Gene 3553] {aka IL-1, IL1-BETA, IL1F2, IL1beta}, CST3 (cystatin C) [NCBI Gene 1471] {aka ADLDWA, ARMD11, HEL-S-2}, APP (amyloid beta precursor protein) [NCBI Gene 351] {aka AAA, ABETA, ABPP, AD1, APPI, CTFgamma}, HBA1 (hemoglobin subunit alpha 1) [NCBI Gene 3039] {aka ECYT7, HBA-T3, HBH, METHBA}
- **Diseases:** Frailty (MESH:D000073496), hearing loss (MESH:D034381), metabolic dysregulation (MESH:D021081), chronic obstructive airway disease (MESH:D029424), fatigue (MESH:D005221), amyotrophic lateral sclerosis-Parkinsonism-dementia (OMIM:105500), post-stroke (MESH:D020521), vitamin D (MESH:D014808), White matter lesions (MESH:D056784), TBI (MESH:D000070642), anxiety (MESH:D001007), atrophy (MESH:D001284), MCI (MESH:D060825), AD (MESH:D000544), neurotoxic (MESH:D020258), diabetes (MESH:D003920), head trauma (MESH:D006259), neurodegeneration (MESH:D019636), multi-infarct dementia (MESH:D015161), inflammatory (MESH:D007249), tooth loss (MESH:D016388), cognitive decline (MESH:D003072), ALS (MESH:D008113), memory impairment (MESH:D008569), infectious diseases (MESH:D003141), Human Immunodeficiency Virus (HIV) infection (MESH:D015658), FTD (MESH:D057180), amyloid (MESH:C000718787), Dementia (MESH:D003704), Parkinsonism (MESH:D010302), type 2 diabetes (MESH:D003924), PwD (MESH:C000719191), verbal fluency impairment (MESH:D013064), soil mineral deficiencies (MESH:D005242), depression (MESH:D003866), weight loss (MESH:D015431), MTBI (MESH:D001924), FTLD (MESH:D057174), neurocognitive disorder (MESH:D019965), atrial fibrillation (MESH:D001281), hypertension (MESH:D006973), VD (MESH:D015140), micronutrient deficiencies (MESH:D007153), malnutrition (MESH:D044342), PDC (MESH:C537181), burnout (MESH:D002055), Parkinsonism-dementia (MESH:C537240), epilepsy (MESH:D004827)
- **Chemicals:** FDG (MESH:D019788), MDA (MESH:D008315), citicoline (MESH:D003566), LDL-C (-)
- **Species:** Cymbopogon citratus (lemon grass, species) [taxon 66014], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12970937/full.md

## References

133 references — full list in the complete paper: https://tomesphere.com/paper/PMC12970937/full.md

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Source: https://tomesphere.com/paper/PMC12970937