Expression of Concern: Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: Possible role of the Akt/GSK3β signaling pathway
Abstract
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TopicsHydrogen's biological and therapeutic effects · Acupuncture Treatment Research Studies · Magnesium in Health and Disease
After this article [1] was published, concerns were raised regarding results presented in Figs 1, 3, 6 and 7, and compliance with the PLOS Animal Research policy. Specifically,
The first author AS stated that Fig 7C was wrongly placed, but that the associated merged panel (Fig 7D) is correct. They provided an updated Fig 7 with a corrected panel C, which has been included with this notice as S1 File. The underlying images for this figure were not provided upon editorial request.
The authors did not respond to editorial requests for comment on the remainder of the concerns.
The PLOS One Editors issue this Expression of Concern to notify readers of the above concerns.
Supporting information
S1 FileUpdated Figure 7.(TIF)
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Hong Y, Shao A, Wang J, Chen S, Wu H, Mc Bride DW, et al. Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: Possible role of the Akt/GSK 3β signaling pathway. P Lo S One. 2014;9(4):e 96212. doi: 10.1371/journal.pone.0096212 24763696 PMC 3999200 · doi ↗ · pubmed ↗
- 2Huang Q, Wang G, Hu Y-L, Liu J-X, Yang J, Wang S, et al. Study on the expression and mechanism of inflammatory factors in the brain of rats with cerebral vasospasm. Eur Rev Med Pharmacol Sci. 2017;21(12):2887–94. 28682429 · pubmed ↗
- 3Huang Q, Wang G, Hu Y-L, Liu J-X, Yang J, Wang S, et al. Retraction Note: Study on the expression and mechanism of inflammatory factors in the brain of rats with cerebral vasospasm. Eur Rev Med Pharmacol Sci. 2024;28(14):3969. doi: 10.26355/eurrev_202407_36580 39081154 · doi ↗ · pubmed ↗
- 4Shao A, Guo S, Tu S, Ammar A, Tang J, Hong Y, et al. Astragaloside IV alleviates early brain injury following experimental subarachnoid hemorrhage in rats. Int J Med Sci. 2014;11(10):1073–81. doi: 10.7150/ijms.9282 25136262 PMC 4135229 · doi ↗ · pubmed ↗