# Habitual coffee consumption poorly correlates with sleep quality and daytime sleepiness: A cross-sectional study

## TL;DR

This study finds that regular coffee drinking has a weak link to sleep quality and daytime sleepiness in a large group of people.

## Contribution

The study provides new evidence on the long-term effects of coffee consumption on sleep using a large cohort and genetic data.

## Key findings

- Coffee consumption showed very low association with sleep habits or daytime sleepiness.
- Genetic variants confirmed habitual coffee intake but did not strongly correlate with sleep outcomes.
- Adaptive mechanisms in the adenosine system may reduce caffeine's impact on sleep in regular users.

## Abstract

Coffee is the most common drink in the world, second only to water. This makes caffeine, the ingredient of coffee known for its wakefulness-promoting effects, one of the most used psychoactive substances. The psychoactive property of caffeine is well-characterized, and entails its interaction with the adenosine receptors, involved in sleep regulation. While studies have shown a deleterious immediate effect of caffeine on sleep, less is known about the effects of chronic caffeine exposure. In the present cross-sectional study, we investigated this relationship across a large cohort of 30,154 individuals participating in the Swedish Cardiopulmonary Bioimage Study (SCAPIS), which allowed us to compare habitual coffee intake with sleep habits, subjective estimate of daytime sleepiness, and underlying genetic variants. According to our analyses, different degrees of coffee consumption, confirmed by statistical association with previously reported genetic variants, showed very low association with estimated patterns of sleep habits or perceived daytime sleepiness. These results indicate that coffee may be less impactful on sleep habits than previously thought, or that other mechanisms, such as the adaptive capabilities of the adenosine system in adult coffee users, may dampen its psychoactive potency.