# Myelodysplastic Syndrome (MDS) With KMT2A::CBL Rapidly Progressed to Acute Myeloid Leukaemia (AML)

**Authors:** Ke Xu, Temenuzhka Boneva, Elisabeth Nacheva

PMC · DOI: 10.1002/jha2.70260 · EJHaem · 2026-03-09

## Full-text entities

- **Genes:** CD33 (CD33 molecule) [NCBI Gene 945] {aka CD33rSiglec, SIGLEC-3, SIGLEC3, p67}, FUT4 (fucosyltransferase 4) [NCBI Gene 2526] {aka CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX}, CD34 (CD34 molecule) [NCBI Gene 947], SRSF2 (serine and arginine rich splicing factor 2) [NCBI Gene 6427] {aka PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b}, CD19 (CD19 molecule) [NCBI Gene 930] {aka B4, CVID3}, ITGAM (integrin subunit alpha M) [NCBI Gene 3684] {aka CD11B, CR3A, HNA-4, MAC-1, MAC1A, MO1A}, CD22 (CD22 molecule) [NCBI Gene 933] {aka SIGLEC-2, SIGLEC2}, KIT (KIT proto-oncogene, receptor tyrosine kinase) [NCBI Gene 3815] {aka C-Kit, CD117, MASTC, PBT, SCFR}, CD14 (CD14 molecule) [NCBI Gene 929], NCAM1 (neural cell adhesion molecule 1) [NCBI Gene 4684] {aka CD56, MSK39, NCAM}, CUX1 (cut like homeobox 1) [NCBI Gene 1523] {aka CASP, CDP, CDP/Cut, CDP1, COY1, CUTL1}, KMT2A (lysine methyltransferase 2A) [NCBI Gene 4297] {aka ALL-1, ALL1, CXXC7, GAS7, HRX, HTRX}, TET2 (tet methylcytosine dioxygenase 2) [NCBI Gene 54790] {aka IMD75, KIAA1546, MDS}, DIS3 (DIS3 exosome endoribonuclease and 3'-5' exoribonuclease) [NCBI Gene 22894] {aka 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p}
- **Diseases:** MDS (MESH:D009190), ICC (MESH:C566123), CMML (MESH:D015477), ring sideroblast (MESH:D012303), anaemia (MESH:D000743), AML (MESH:D054218), multiple lineage dysplasia (MESH:D015456), monocytosis (MESH:C538328), neutropenia (MESH:D009503)
- **Chemicals:** DAPI (MESH:C007293), Iron (MESH:D007501)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** p.Leu500Ile, p.Tyr867Ter, p.Pro95Arg

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## References

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Source: https://tomesphere.com/paper/PMC12970265