# First person – Louis Widom

## TL;DR

This paper discusses how antibiotics affect bacterial vesicles and their impact on human cells, as explored by Louis Widom in his research.

## Contribution

The study introduces new insights into how antibiotics influence bacterial extracellular vesicles and their effects on endothelial cells.

## Key findings

- Antibiotics modulate the production of Escherichia coli-derived extracellular vesicles.
- These vesicles upregulate ICAM-1 in human endothelial cells.
- The research explores the role of bacterial vesicles in sepsis and blood-brain barrier disruption.

## Abstract

First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping researchers promote themselves alongside their papers. Louis Widom is first author on ‘
Antibiotics modulate Escherichia coli-derived bacterial extracellular vesicle production and their upregulation of ICAM-1 in human endothelial cells’, published in BiO. Louis is a PhD candidate in the lab of Thomas R. Gaborski at the Rochester Institute of Technology, Rochester, USA, investigating the role of pathogenic bacterial extracellular vesicles in sepsis and in disruption of the blood-brain barrier.