# Developmental profiles of infants with hypoxic ischaemic encephalopathy at a tertiary hospital in South Africa

## TL;DR

This study examines the developmental outcomes of infants with hypoxic ischaemic encephalopathy in South Africa, finding that severe cases and lack of cooling treatment lead to worse results.

## Contribution

The study provides new insights into the impact of HIE severity and therapeutic hypothermia on neurodevelopmental outcomes in a South African hospital setting.

## Key findings

- Severe HIE infants had significantly higher rates of neurodevelopmental impairment and cerebral palsy compared to moderate HIE infants.
- Therapeutic hypothermia was associated with reduced rates of neurodevelopmental impairment and cerebral palsy in both moderate and severe HIE groups.
- Developmental scores at 1 year were average, but severe HIE infants had the worst outcomes.

## Abstract

Hypoxic ischaemic encephalopathy (HIE) is a common cause of neonatal death and severe neurological deficit in children, contributing to medico-legal litigation.

To describe the neurodevelopmental outcomes of infants with moderate and severe HIE at Chris Hani Baragwanath Academic Hospital and the proportions with neurodevelopmental impairment (NDI) and complications. To explore the effect of HIE severity and therapeutic hypothermia (TH) on neurodevelopmental outcome.

A retrospective, descriptive study at the Neonatal Neurodevelopmental Clinic included 239 infants with moderate and severe HIE, between 2015 and 2020. Neurodevelopmental outcomes were assessed by using the Griffiths Mental Developmental Scales at 1 year. General Quotient (GQ) scores defined NDI. Clinical and investigation criteria determined those with neurological complications.

Of the 239 infants, 211 (88.3%) and 28 (11.7%) had moderate HIE and severe HIE, respectively. Cerebral palsy (CP) was diagnosed in 9.2% and NDI in 17.1%. Severe HIE infants had significantly higher rates of NDI and CP, 50% (14) and 21.4% (6) respectively, as compared to those of moderate HIE infants, who had 12.7% (27) NDI and 7.6% (16) CP; 152(72%) moderate and 14 (50%) severe HIE infants received TH. Those who received TH were less likely to have NDI (p = 0.005), CP (p = 0.002), epilepsy and visual impairment.

Developmental scores at 1 year of age were in the average range for the cohort, with equivalent profiles across domains. Those with severe HIE had the worst outcomes. Therapeutic hypothermia was associated with decreased CP and NDI in both groups.

This report supports the use of TH as a neuroprotective strategy in stage 2 and 3 HIE, highlighting the need for neurodevelopmental assessments at 2 years and beyond to determine longer-term outcomes and subtle deficits.