# Comparative effectiveness of robotic and video assisted thoracic surgery for lung cancer across key outcomes

**Authors:** Guohang Shen, Ruoyan Wang, Jingyi Xu, Jingwen Chen, Ruoyu Chen, Yiru Wang, Xianquan Zhang, Kaiyong Wang, Yupei Dai, Junfeng Li

PMC · DOI: 10.1016/j.isci.2026.114898 · iScience · 2026-02-03

## TL;DR

This study compares robotic and video-assisted surgeries for lung cancer, finding similar outcomes but differences in cost and recovery time.

## Contribution

The study provides a comprehensive meta-analysis comparing RATS and VATS across multiple clinical and economic outcomes.

## Key findings

- RATS had lower conversion to thoracotomy rates and less blood loss compared to VATS.
- RATS showed more extensive lymphadenectomy and higher R0 resection rates.
- Hospitalization costs were higher for RATS, but 30- and 90-day mortality were similar.

## Abstract

Robotic-assisted thoracic surgery (RATS) and video-assisted thoracoscopic surgery (VATS) are widely used for minimally invasive resection of pulmonary tumors, but they differ in technical capabilities and resource demands. We conducted a PRISMA-based systematic review and meta-analysis of randomized and cohort studies identified by searching PubMed, Embase, Web of Science, Scopus, and the Cochrane Library through June 2025. Across 25 studies including 41,417 patients, RATS was associated with lower conversion to thoracotomy rates and less blood loss, more extensive lymphadenectomy, higher R0 resection rates, and shorter chest tube duration, ICU stay, and hospital stay. Pneumonia and atrial fibrillation were less frequent, whereas overall complications, pneumothorax, and 30- and 90-day mortality were similar. Hospitalization costs were higher, and pooled survival data suggested a possible long-term advantage. These findings clarify platform tradeoffs and motivate large randomized trials and cost-effectiveness analyses.

•RATS was compared with VATS for surgical treatment of non-small cell lung cancer•R0 resection rates and lymph node yield were comparable between RATS and VATS•Perioperative outcomes and major postoperative complications were similar•Costs and 5-year overall survival were assessed to benchmark RATS versus VATS

RATS was compared with VATS for surgical treatment of non-small cell lung cancer

R0 resection rates and lymph node yield were comparable between RATS and VATS

Perioperative outcomes and major postoperative complications were similar

Costs and 5-year overall survival were assessed to benchmark RATS versus VATS

Health sciences; Medicine; Surgery; Oncology

## Linked entities

- **Diseases:** lung cancer (MONDO:0005138), non-small cell lung cancer (MONDO:0005233), pneumonia (MONDO:0005249), atrial fibrillation (MONDO:0004981), pneumothorax (MONDO:0002076)

## Full-text entities

- **Diseases:** COPD (MESH:D029424), Pneumonia (MESH:D011014), mediastinal (MESH:D008480), NSCLC (MESH:D002289), respiratory complications (MESH:D012140), death (MESH:D003643), blood (MESH:D006402), tremor (MESH:D014202), atelectasis (MESH:D001261), inflammatory (MESH:D007249), complications (MESH:D008107), trauma (MESH:D014947), Blood loss (MESH:D016063), DM (MESH:D009223), Cancer of the lung (MESH:D008175), Postoperative complication (MESH:D011183), postoperative pain (MESH:D010149), Cancer (MESH:D009369), pneumothorax (MESH:D011030), atrial fibrillation (MESH:D001281), diabetes (MESH:D003920), RATS (MESH:D013896)
- **Chemicals:** OPEN (-), carbon (MESH:D002244)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

10 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12969034/full.md

## References

43 references — full list in the complete paper: https://tomesphere.com/paper/PMC12969034/full.md

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Source: https://tomesphere.com/paper/PMC12969034