# An Open‐Label Study to Assess the Efficacy and Tolerability of a Multifunctional, 10‐Peptide Face and Neck Serum to Address Skin Quality

## TL;DR

A 12-week study found that a 10-peptide serum improved skin quality and boosted user satisfaction for both regular and advanced skincare users.

## Contribution

Demonstrates the efficacy of a novel 10-peptide serum in improving facial and neck skin quality across different skincare routines.

## Key findings

- 89.6% of subjects showed clinical improvement in skin quality by Week 12.
- Most subjects (52%) achieved moderate-to-marked global improvement.
- The serum was well-tolerated and highly satisfactory across both user groups.

## Abstract

There is increasing patient demand for improved skin quality and the desire to achieve rejuvenated skin and improve self‐confidence.

The objective of this 12‐week study was to assess changes in skin quality and subject satisfaction after using a novel anti‐aging 10‐peptide serum (Pep Up Collagen Boost Face & Neck Serum; Colorescience Inc., Carlsbad, CA).

Healthy adult subjects seeking facial and neck skin rejuvenation (N = 48) were divided into two groups. Group A included subjects not currently using prescription, medical grade, advanced, or physician‐dispensed skincare products and Group B included subjects who currently were using such products. Subjects in both groups applied the anti‐aging peptide serum twice daily as part of their daily skincare routine for 12 weeks and were evaluated after 4, 8, and 12 weeks of treatment. Improvements in Global Skin condition and other parameters associated with skin quality were assessed by three investigators.

By Week 12, 89.6% of subjects showed clinical improvement (p < 0.01), with most (52%) achieving moderate‐to‐marked global improvement. Both groups had median global scores of 3.0, with similar mean scores (Group A, 2.6; Group B, 2.8). Subjects in both groups indicated improvements in global scores (Group A, 91.7%; Group B, 87.5%) and most subjects in both groups demonstrated marked improvements from baseline (54.2% and 50.0%). The product was well‐tolerated and subject satisfaction was high.

The twice‐daily application of a novel anti‐aging 10‐peptide serum restores several markers of facial and neck skin quality that were incremental to basic skincare routines and professional skincare regimens.