# Culture‐Negative Infective Endocarditis Presenting With Cardio‐Hepatorenal Syndrome in a 21‐Year‐Old Patient: A Case Report of Diagnostic Workup and Management

## TL;DR

A 21-year-old man with culture-negative infective endocarditis presented with rare cardio-hepatorenal symptoms, highlighting diagnostic challenges and the need for careful management.

## Contribution

This case report presents a rare instance of culture-negative infective endocarditis in a young, previously healthy patient.

## Key findings

- The patient exhibited dyspnea and jaundice, indicating a rare cardio-hepatorenal syndrome.
- Culture-negative results complicated diagnosis and treatment decisions.
- The case emphasizes the importance of maintaining a high suspicion for IE despite negative cultures.

## Abstract

Infective endocarditis (IE) imposes a challenge in clinical practice, often demanding rapid and precise identification of the causative agent to guide tailored therapeutic interventions. However, a subset of cases presents an elusive diagnostic dilemma with culture‐negative results, thereby complicating the management strategy. This case report sheds light on a particularly rare instance of culture‐negative IE in a 21‐year‐old previously healthy male who presented with dyspnea and jaundice, emphasizing the scarcity of such cases in the existing medical literature. Through a detailed examination of clinical manifestations, diagnostic modalities, and treatment outcomes, we aim to contribute valuable insights into the nuanced aspects of culture‐negative IE. Furthermore, this report underscores the imperative need for clinicians to maintain a high index of suspicion for IE, even in the absence of positive cultures, to ensure timely and appropriate management for improved patient prognosis.