# The Alzheimer's Association TrialMatch—Increasing awareness of all dementia trials

## TL;DR

The Alzheimer's Association TrialMatch platform helps connect people with dementia research opportunities and shows how many participants are still needed for studies.

## Contribution

TrialMatch is a centralized, open-access tool that tracks and promotes dementia research opportunities with broad inclusion criteria.

## Key findings

- TrialMatch received over 122,000 web sessions and 18,802 calls, referring 17,725 people to dementia studies.
- Over 1.8 million participants are still needed to complete ongoing U.S. dementia research studies.
- The platform tracks data for 587 dementia research opportunities, more than previous restrictive analyses.

## Abstract

Roughly 7.2 million older Americans are living with Alzheimer's disease (AD). Research participation remains one of the largest barriers facing dementia research advancements.

TrialMatch is a dementia research awareness tool. TrialMatch consolidates research opportunities to serve as an open‐access, centralized, and user‐friendly resource to identify research opportunities. Between August 2020 and June 2024, we tracked the number of research opportunities available, enrollment targets, and TrialMatch engagement.

TrialMatch maintained a database of over 700 opportunities and received 18,802 calls and 122,461 web sessions, and provided 17,725 referrals to opportunities. An estimated 1,867,403 participants are needed to populate all the ongoing studies in the United States.

By using a broad inclusion criteria, TrialMatch highlights the burden that AD/ADRD research faces with recruitment. While TrialMatch has demonstrated its ability to serve as an awareness tool, future analyses are needed to better evaluate the impact of the tool on enrollment.

Over a 4‐year review period, the Alzheimer's Association's TrialMatch platform received 18,802 calls to its support line, 122,461 active web sessions, and provided 17,725 referrals to dementia research studies.Based on a review of all dementia research studies included in TrialMatch, a total of 1,867,403 participants are needed to complete all ongoing studies.The TrialMatch database contains enrollment data for 587 dementia research opportunities, which is far more than more restrictive analyses looking at clinical trials have analyzed previously.

Over a 4‐year review period, the Alzheimer's Association's TrialMatch platform received 18,802 calls to its support line, 122,461 active web sessions, and provided 17,725 referrals to dementia research studies.

Based on a review of all dementia research studies included in TrialMatch, a total of 1,867,403 participants are needed to complete all ongoing studies.

The TrialMatch database contains enrollment data for 587 dementia research opportunities, which is far more than more restrictive analyses looking at clinical trials have analyzed previously.