# Diagnostic accuracy of artificial intelligence in detection of ovarian cancer—a pilot study

**Authors:** Dipanwita Banerjee, Ashok Sharma, Ekta Dhamija, Sahar Qazi, Sandeep R. Mathur, Neerja Bhatla

PMC · DOI: 10.3389/fmed.2026.1729412 · Frontiers in Medicine · 2026-02-23

## TL;DR

This pilot study shows that machine learning can accurately detect ovarian cancer from benign tumors using patient data.

## Contribution

The study demonstrates high diagnostic accuracy of machine learning models for ovarian cancer detection.

## Key findings

- Random forest and support vector machine achieved 85.87% and 83.05% accuracy, respectively.
- The maximum AUROC of 0.92 was observed in the random forest model.

## Abstract

To investigate a panel of variables using four machine learning based classifiers, i.e., support vector machine (SVM), random forest (RF), artificial neural network (ANN) and logistic regression (LR) to make a diagnosis of ovarian cancer, differentiating it from benign ovarian masses.

A prospective observational pilot study was done between November 2021 and June 2023. Following data pre-processing to ensure compatibility with ML models, four ML algorithms, i.e., support vector machine (SVM), logistic regression (LR), random forest (RF) and artificial neural network (ANN) were tested by multimodal parameters from the datasets of 50 patients presenting with suspected epithelial ovarian cancer (Group A) or benign ovarian tumour (Group B). Statistical analysis was done using STATA version 14.0.

We found that the machine learning approach could predict malignant tumours with appreciably high accuracy similar to a few studies done so far in this field. All four ML algorithms showed high level of accuracy with a maximum AUROC of 0.92 in the RF model. Both RF and SVM had an accuracy of 85.87 and 83.05%.

The ML algorithms can detect ovarian cancers with a high level of accuracy. Further, a large-volume prospective study on large volume data sets is required before inclusion of ML algorithms in clinical practice.

## Linked entities

- **Diseases:** ovarian cancer (MONDO:0005140), benign ovarian tumour (MONDO:0000646)

## Full-text entities

- **Genes:** CEACAM3 (CEA cell adhesion molecule 3) [NCBI Gene 1084] {aka CD66D, CEA, CGM1, CGM1a, W264, W282}, MUC16 (mucin 16, cell surface associated) [NCBI Gene 94025] {aka CA125}
- **Diseases:** ascites (MESH:D001201), metastases (MESH:D009362), mucinous cystadenoma (MESH:D018291), endometrioma (MESH:D004715), CD (MESH:D003424), mucinous carcinoma (MESH:D002288), peritoneal carcinomatosis (MESH:D010534), benign and (MESH:D009369), peritoneal (MESH:D010538), mature cystic teratoma (MESH:D013724), serous cystadenoma (MESH:D018293), adnexal mass (MESH:D000291), DL (MESH:C537113), serous cystadeno-fibroma (MESH:D005350), leiomyoma (MESH:D007889), AI (MESH:C538142), ML (MESH:D007859), EOC (MESH:D000077216), Benign ovarian tumours (MESH:D010051), omental disease (MESH:D015436), benign ovarian masses (MESH:D010049), endometrioid and clear cell carcinoma (MESH:D002292), distension of abdomen (MESH:D000006)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12968258/full.md

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12968258/full.md

## References

25 references — full list in the complete paper: https://tomesphere.com/paper/PMC12968258/full.md

---
Source: https://tomesphere.com/paper/PMC12968258