# Emergency rectal cancer: clinical presentation and therapeutic options

**Authors:** Wanda Luisa Rita Petz, Olivier Gié, Rosita Sortino, Piercarlo Saletti

PMC · DOI: 10.3389/fsurg.2026.1778350 · Frontiers in Surgery · 2026-02-23

## TL;DR

This paper discusses how some rectal cancer patients present in emergencies and explores treatment options and outcomes.

## Contribution

The paper provides a focused review on emergency presentations of rectal cancer and their corresponding therapeutic strategies.

## Key findings

- Emergency rectal cancer often presents as bowel obstruction, perforation, or bleeding.
- Treatment depends on patient condition, tumor location, and includes surgery and chemoradiotherapy.
- Healthcare policies to reduce emergency cases are also discussed.

## Abstract

Up to 20% of rectal cancer patients experience complications that result in an emergency presentation at diagnosis, the more frequent scenarios being represented by large bowel obstruction or perforation and tumor bleeding. The treatment of emergency rectal cancer depends both on patients' clinical conditions and risk factors, and on tumor's characteristics, primarily its intra- or extraperitoneal location. This article will address the different clinical presentations and the corresponding available treatments, with a particular focus on surgical techniques and multimodal chemoradiotherapy. In addition, it will address the prognosis of emergency rectal cancers and discuss healthcare policy strategies aimed at minimizing its occurrence.

## Linked entities

- **Diseases:** rectal cancer (MONDO:0006519)

## Full-text entities

- **Genes:** ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}, KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845] {aka 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A}, BRAF (B-Raf proto-oncogene, serine/threonine kinase) [NCBI Gene 673] {aka B-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1}
- **Diseases:** TNT (MESH:D016609), gastrointestinal (MESH:D005767), ataxia-telangiectasia (MESH:D001260), peritonitis (MESH:D010538), anastomotic leak (MESH:D057868), cerebrovascular disease (MESH:D002561), nodal (MESH:D013611), wound infection (MESH:D014946), toxicity (MESH:D064420), anemia (MESH:D000740), metastases (MESH:D009362), hypertension (MESH:D006973), neutropenia (MESH:D009503), tremor (MESH:D014202), colon and rectal cancer (MESH:D015179), atherosclerosis (MESH:D050197), visceral obesity (MESH:D056128), HIV infection (MESH:D015658), Fournier's gangrene (MESH:D018934), necrosis (MESH:D009336), fistula (MESH:D005402), oncological disease (MESH:D000072716), ureteral obstruction (MESH:D014517), LGIB (MESH:D006471), sepsis (MESH:D018805), acute abdomen (MESH:D000006), diverticular disease (MESH:D000076385), infectious (MESH:D003141), Fanconi's anemia (MESH:D005199), chronic pain (MESH:D059350), abdominal bleeding (MESH:D000007), Chronic Inflammatory Bowel Diseases (MESH:D015212), perforation (MESH:D057112), peripheral neuropathy (MESH:D010523), intestinal obstruction (MESH:D007415), dementia (MESH:D003704), ileus (MESH:D045823), diabetes (MESH:D003920), pulmonary complications (MESH:D008171), collagen vascular diseases (MESH:D014652), rectal adenocarcinoma (MESH:D000230), postoperative pain (MESH:D010149), Tumor (MESH:D009369), rectal bleeding (MESH:D012002), pneumoperitoneum (MESH:D011027), abdominal pain (MESH:D015746), blood loss (MESH:D016063), LARC (MESH:D012004), bowel (MESH:D012778), inflammation (MESH:D007249), abscess (MESH:D000038), fibrosis (MESH:D005355), pain (MESH:D010146), ischemia (MESH:D007511), hemi- and paraplegia (MESH:C565524), hypoxia (MESH:D000860), vomiting (MESH:D014839), Perforated tumors (MESH:D007416), Nijmegen break- age syndrome (MESH:D049932), chronic proctitis (MESH:D011349)
- **Chemicals:** indocyanine-green (MESH:D007208), TNT (-), FOLFOX (MESH:C410216), argon (MESH:D001128), epinephrine (MESH:D004837)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

96 references — full list in the complete paper: https://tomesphere.com/paper/PMC12967934/full.md

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Source: https://tomesphere.com/paper/PMC12967934