# A novel therapeutic strategy of methicillin-resistant Staphylococcus aureus

## TL;DR

This paper presents a new method to treat antibiotic-resistant Staphylococcus aureus infections by causing bacterial calcification and boosting the immune response.

## Contribution

The novel approach uses antibody-polysialic acid conjugates to induce calcification and modulate immune responses in MRSA infections.

## Key findings

- Antibody-polysialic acid conjugates target wall teichoic acids to induce bacterial calcification.
- The strategy enhances calprotectin expression and activates macrophages to modulate host immune responses.
- This method shows promise for treating chronic methicillin-resistant S. aureus infections.

## Abstract

Staphylococcus aureus is a major public health threat, largely due to its remarkable capacity to develop antimicrobial resistance. Zhang et al. recently demonstrated a highly innovative approach to eradicate chronic methicillin-resistant S. aureus infections by inducing bacterial calcification with antibody-polysialic acid conjugates targeting wall teichoic acids, while simultaneously modulating host immune responses via enhanced calprotectin expression and macrophage activation. Despite limitations, this strategy represents a promising and unconventional therapy to combat resistant S. aureus infections.

Image, graphical abstract