# Large-Volume Pneumoperitoneum in a Neonate: A Rare Case of Necrotizing Gastritis

**Authors:** Khaled Saed, Kayla L Haydon, Shree Patel, Gerald Gutwein, Logan Broome, Marthena Phan, Ameer Al-Hadidi, Leopoldo Malvezzi

PMC · DOI: 10.7759/cureus.103120 · Cureus · 2026-02-06

## TL;DR

A rare case of a newborn with a severe stomach perforation is reported, highlighting the need for quick diagnosis and surgery to improve survival.

## Contribution

This paper presents a rare clinical case of neonatal spontaneous gastric perforation with large-volume pneumoperitoneum and necrotizing gastritis.

## Key findings

- A two-day-old male presented with spontaneous gastric gangrene and perforation requiring emergency surgery.
- Large-volume pneumoperitoneum was identified as a key indicator of necrotizing gastritis in neonates.
- The patient recovered and began tolerating feeds by postoperative day 8.

## Abstract

Neonatal spontaneous gastric perforations are rare but are associated with high mortality rates. They usually occur within the first week of life, with a sudden onset of abdominal distension. Imaging often shows pneumoperitoneum. Gastric perforations require emergent surgical management.

We report a case of a two-day-old male with spontaneous patchy gastric gangrene and perforation of the greater curvature. The patient presented with abdominal distension after initiation of feeds. An X-ray of the abdomen revealed a large-volume pneumoperitoneum. The patient underwent emergent exploratory laparotomy, partial segmental gastrectomy, and primary closure in two layers. The patient started tolerating feeds on postoperative day 8.

Our case underscores the importance of considering neonatal spontaneous gastric perforation in the differential diagnosis of pneumoperitoneum. Large-volume pneumoperitoneum is a pathognomonic finding of necrotizing gastritis and gastric perforation in neonates and can lead to fatal respiratory decompensation. Early diagnosis and surgical intervention are imperative to improve prognosis.

## Linked entities

- **Diseases:** necrotizing gastritis (MONDO:0002845)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Diseases:** pneumatosis (MESH:D011006), systemic illness (MESH:D012140), placenta previa (MESH:D010923), intrauterine growth restriction (MESH:D005317), inflammatory disease (MESH:D007249), gastric or bowel injury (MESH:D013276), shock (MESH:D012769), trauma (MESH:D014947), Pneumoperitoneum (MESH:D011027), pre-eclampsia (MESH:D011225), intra-abdominal infection (MESH:D059413), weakness (MESH:D018908), maternal diabetes (MESH:D003920), Gastric perforations (MESH:D013274), respiratory (MESH:D012131), hypoxia (MESH:D000860), respiratory distress (MESH:D012128), gastric ischemia (MESH:D007511), hypertension (MESH:D006973), metabolic acidosis (MESH:D000138), leukocytosis (MESH:D007964), premature rupture of membranes (MESH:D005322), leak (MESH:D019559), peritonitis (MESH:D010538), amniotic infection (MESH:D007239), perforation (MESH:D057112), abdominal distension (MESH:D000007), NEC (MESH:D020345), mucosal injury (MESH:D052016), gastric (MESH:D013272), sepsis (MESH:D018805), necrosis (MESH:D009336), gangrene (MESH:D005734), uterine cord prolapse (MESH:D014596), Necrotizing Gastritis (MESH:D005756)
- **Chemicals:** oxygen (MESH:D010100), lactic acid (MESH:D019344), meropenem (MESH:D000077731), vancomycin (MESH:D014640), ceftazidime (MESH:D002442), HCO3- (MESH:D001639), piperacillin-tazobactam (MESH:D000077725), steroid (MESH:D013256), carbon dioxide (MESH:D002245), ampicillin (MESH:D000667), labetalol (MESH:D007741)
- **Species:** Nicotiana tabacum (American tobacco, species) [taxon 4097], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12967819/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12967819/full.md

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Source: https://tomesphere.com/paper/PMC12967819