# Beyond the Appendix: Unveiling Florid Lymphoid Hyperplasia

**Authors:** Apoorva Raichur, Girish Bakhshi

PMC · DOI: 10.7759/cureus.103103 · Cureus · 2026-02-06

## TL;DR

This paper discusses a rare condition called Florid Lymphoid Hyperplasia that can mimic acute appendicitis, making accurate diagnosis challenging.

## Contribution

The paper presents a case study highlighting the diagnostic challenges of FLH due to its similarity to acute appendicitis.

## Key findings

- FLH can closely mimic acute appendicitis in clinical presentation.
- Accurate diagnosis of FLH requires careful evaluation due to its similarity to other acute abdominal conditions.

## Abstract

Florid lymphoid hyperplasia (FLH) is a rare entity with an unknown etiology. It may occur anywhere in the gastrointestinal tract, from the base of the tongue to the anus, but is more common at the terminal ileum and rectum. It often presents as an acute abdominal condition. Our case illustrates how FLH can closely mimic the clinical presentation of acute appendicitis. The resemblance can be so striking that it poses a significant diagnostic challenge, highlighting the importance of careful evaluation in such scenarios.

## Linked entities

- **Diseases:** acute appendicitis (MONDO:0005649)

## Full-text entities

- **Genes:** KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, BCL2 (BCL2 apoptosis regulator) [NCBI Gene 596] {aka Bcl-2, PPP1R50}
- **Diseases:** FLH (MESH:D019310), cancer (MESH:D009369), adenocarcinoma (MESH:D000230), mesenteric lymphadenopathy (MESH:D008639), Gardner syndrome (MESH:D005736), metastatic disease (MESH:D000092182), abdominal pain (MESH:D015746), ileocecal malignancy (MESH:D044504), inflammation (MESH:D007249), dysplasia (MESH:D015792), multiple intestinal polyposis (MESH:D044483), pain (MESH:D010146), fever (MESH:D005334), vomiting (MESH:D014839), mass (MESH:C536030), Yersinia (MESH:D015009), nausea (MESH:D009325), febrile (MESH:D000071072), diarrhea (MESH:D003967), appendix (MESH:D001063), COVID-19 (MESH:D000086382), Crohn's disease (MESH:D003424), leukocytosis (MESH:D007964), ulcers (MESH:D014456), MALT lymphoma (MESH:D018442), Adenovirus infection (MESH:D000257), follicular lymphoma (MESH:D008224), acute appendicitis (MESH:D001064), terminal (MESH:D007153), follicular hyperplasia (MESH:D006965), rigidity (MESH:D009127), necrosis (MESH:D009336), chronic (MESH:D002908), ileal lymphoid hyperplasia (MESH:D007077), Campylobacter (MESH:D002169), inflammatory bowel disease (MESH:D015212), Enteritis follicularis (MESH:D004751), Shigella (MESH:D004405), Infectious ileitis (MESH:D007079), lymphoma (MESH:D008223), tenderness (MESH:D063806), non-Hodgkin's lymphoma (MESH:D008228), systemic (MESH:D015619), granulomas (MESH:D006099), constipation (MESH:D003248), carcinoid tumor (MESH:D002276)
- **Species:** Adenoviridae (family) [taxon 10508], Homo sapiens (human, species) [taxon 9606], Shigella (genus) [taxon 620]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12967804/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12967804/full.md

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Source: https://tomesphere.com/paper/PMC12967804