# Enormous Aneurysm of the Deep Femoral Artery: A Case Report

**Authors:** Nektarios Galanis, Christos Lyrtzis, Lamprini Navrozidou, Georgios Trikoilis, Pirro Majko, George Paraskevas

PMC · DOI: 10.7759/cureus.104795 · Cureus · 2026-03-06

## TL;DR

A rare case of a large aneurysm in the deep femoral artery is reported, highlighting diagnostic and ethical challenges in a patient with multiple myeloma.

## Contribution

This case report presents a rare instance of a large isolated deep femoral artery aneurysm in a patient with multiple myeloma.

## Key findings

- A 5.3 cm isolated deep femoral artery aneurysm was identified in a 77-year-old male with multiple myeloma.
- CT angiography revealed a fusiform aneurysm with significant mural thrombus and irregular ulcerations.
- The patient opted for conservative management despite surgical recommendations due to ethical and clinical considerations.

## Abstract

Isolated true aneurysms of the deep femoral artery (DFAA) are exceptionally rare clinical entities. This report aims to describe the diagnostic challenges and therapeutic dilemmas associated with a huge 5.3 cm isolated DFAA in a patient with coexisting systemic hematological malignancy. A 77-year-old male patient with multiple myeloma underwent radiographic investigation for skeletal pain, which incidentally identified a 5.3 cm isolated left DFAA. Multi-planar CT angiography (CTA) characterized the lesion as a 10-cm long fusiform aneurysm featuring significant mural thrombus (3.7 cm thick) and irregular luminal ulcerations. Given the high risk of rupture, open surgical excision and ligation were recommended. However, following comprehensive clinical counseling regarding the natural history of the disease, the patient opted for conservative management with watchful waiting. Isolated DFAAs of this magnitude are rare and may be clinically masked by systemic pathologies such as multiple myeloma. This case highlights the diagnostic utility of CTA in characterizing complex vascular lesions and illustrates the ethical challenges that arise when patients decline indicated surgical treatment.

## Linked entities

- **Diseases:** multiple myeloma (MONDO:0009693)

## Full-text entities

- **Diseases:** pain (MESH:D010146), fracture (MESH:D050723), inguinal hernia (MESH:D006552), hyperlipidemia (MESH:D006949), trauma (MESH:D014947), Femoral artery aneurysms (MESH:D002532), inflammation (MESH:D007249), swelling (MESH:D004487), vascular lesions (MESH:D014652), rupture (MESH:D012421), pseudoaneurysms (MESH:D017541), neoplasms (MESH:D009369), renal failure (MESH:D051437), multiple myeloma (MESH:D009101), True aneurysms (MESH:D000783), Marfan Syndrome (MESH:D008382), lymphadenopathy (MESH:D008206), Behcet's disease (MESH:D001528), systemic arteriopathy (MESH:D020212), groin mass (MESH:C536030), hematological malignancy (MESH:D019337), PE (MESH:D011655), ischemia (MESH:D007511), acromegaly (MESH:D000172), atherosclerotic (MESH:D050197), hypertension (MESH:D006973), occlusive disorder (MESH:D001157), thrombosis (MESH:D013927), abdominal aortic aneurysms (MESH:D017544), anemia (MESH:D000740), DVT (MESH:D020246), bone lesions (MESH:D001847), bone and joint pain (MESH:D018771), hypercalcemia (MESH:D006934), vascular (MESH:D057772), numbness (MESH:D006987), infection (MESH:D007239), embolization (MESH:D004617), DFA (MESH:D005266)
- **Chemicals:** DFAA (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12967795/full.md

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Source: https://tomesphere.com/paper/PMC12967795