# Diagnostic Dilemma in Left Ventricular Noncompaction Cardiomyopathy: Thrombus or Tumor?

**Authors:** Mohamed O Elhussain, Mazen Ahmed, Ragda Ali

PMC · DOI: 10.7759/cureus.103100 · Cureus · 2026-02-06

## TL;DR

A patient's heart mass was initially thought to be a tumor but turned out to be a noncompaction cardiomyopathy, highlighting the importance of careful imaging.

## Contribution

Demonstrates the diagnostic challenge of distinguishing thrombus from tumor in LVNC using multimodal imaging.

## Key findings

- A mobile apical mass initially appeared vascular but resolved, suggesting pseudo-enhancement.
- Serial echocardiography revealed prominent trabeculations consistent with LVNC.
- The case underscores the need for multimodal assessment in uncertain intracardiac masses.

## Abstract

Left ventricular noncompaction cardiomyopathy (LVNC) is associated with thromboembolic complications and can complicate intracardiac mass interpretation. A 58-year-old man with prior left ventricular (LV) apical thrombus presented with abdominal pain and weight loss. Contrast-enhanced transthoracic echocardiogram (TTE) showed severe LV dysfunction (left ventricular ejection fraction (LVEF) 15-20%) and a 1.5 cm mobile apical mass with apparent central contrast uptake, raising concern for a tumor in the setting of suspected prostate malignancy. Heparin was initiated. On day 3, the mass had resolved, and repeat echocardiography demonstrated prominent apical trabeculations and a low-flow apex with findings suggestive of LVNC, indicating that the perceived "vascularity" likely reflected pseudo-enhancement. This case emphasizes serial imaging and multimodality assessment when uncertainty persists.

## Linked entities

- **Diseases:** Left ventricular noncompaction cardiomyopathy (MONDO:0018901)

## Full-text entities

- **Genes:** NPPB (natriuretic peptide B) [NCBI Gene 4879] {aka BNP, Iso-ANP}
- **Diseases:** thromboembolic (MESH:D013923), systolic dysfunction (MESH:D006331), embolization (MESH:D004617), heart failure (MESH:D006333), prostate malignancy (MESH:D011472), intracardiac lesion (MESH:C538262), cardiac tumor (MESH:D006338), cardiac metastases (MESH:D009362), LV thrombus (MESH:D013927), weight loss (MESH:D015431), atrial fibrillation (MESH:D001281), prostatic intraepithelial neoplasm (MESH:D019048), blood stasis (MESH:D014647), LV (MESH:D018487), arrhythmias (MESH:D001145), mass (MESH:C536030), neurologic deficits (MESH:D009461), LV apical mass (MESH:D000092183), disease (MESH:D004194), LVNC (MESH:C565277), apical (MESH:D010485), metastatic disease (MESH:D000092182), abdominal pain (MESH:D015746), avascular (MESH:D010020), ischemic (MESH:D002545), Tumor (MESH:D009369)
- **Chemicals:** rivaroxaban (MESH:D000069552), creatinine (MESH:D003404), Heparin (MESH:D006493)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12967793/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12967793/full.md

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Source: https://tomesphere.com/paper/PMC12967793