# Cerebellar Infarction Following Pulseless Electrical Activity Arrest in Advanced Heart Failure With Reduced Ejection Fraction: A Post-resuscitation Diagnostic Pitfall

**Authors:** Cristina Suarez Chiriboga, Saketh Jayanthi, Amber Jin, Iheoma Duruiheoma, Roxana Lazarescu

PMC · DOI: 10.7759/cureus.103092 · Cureus · 2026-02-06

## TL;DR

A patient with heart failure developed a cerebellar stroke after a cardiac arrest, highlighting the need for early brain imaging to avoid misdiagnosis.

## Contribution

Highlights cerebellar infarction as a diagnostic pitfall in post-cardiac arrest patients with heart failure.

## Key findings

- Early CT showed a left cerebellar infarction without cerebral edema.
- MRI four days later showed no acute brain abnormalities.
- Early imaging helps guide post-resuscitation neurological care.

## Abstract

Neurologic deterioration following cardiac arrest is frequently attributed to global hypoxic-ischemic brain injury. However, focal ischemic stroke may occur concurrently and represents an important diagnostic pitfall in post-resuscitation care. We report the case of a 59-year-old woman with end-stage heart failure with reduced ejection fraction who developed acute neurologic impairment following prolonged pulseless electrical activity arrest. Early non-contrast CT of the head demonstrated a focal left cerebellar infarction without diffuse cerebral edema. MRI of the brain performed four days later showed no acute intracranial abnormality, illustrating radiographic discordance between early CT and delayed MRI in posterior circulation ischemia. These complementary imaging findings informed ongoing neurologic assessment and multidisciplinary discussions. This case underscores the importance of early neuroimaging and maintaining a broad neurologic differential diagnosis in post-cardiac arrest patients.

## Linked entities

- **Diseases:** heart failure (MONDO:0005252)

## Full-text entities

- **Genes:** CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}
- **Diseases:** cardiogenic shock (MESH:D012770), endothelial dysfunction (MESH:D014652), cerebral ischemia (MESH:D002545), Posterior circulation infarcts (MESH:D020520), cardiac arrest (MESH:D006323), anasarca (MESH:D004487), critically ill (MESH:D016638), ischemia (MESH:D007511), hypotension (MESH:D007022), neurologic decline (MESH:D009461), hypoxia (MESH:D000860), cerebral edema (MESH:D001929), respiratory failure (MESH:D012131), acquired immunodeficiency syndrome (MESH:D000163), pleural effusions (MESH:D010996), organ failure (MESH:D009102), anoxic injury (MESH:D002534), chronic obstructive pulmonary disease (MESH:D029424), acute stroke (MESH:D020521), hypercapnia (MESH:D006935), cardiovascular toxicity (MESH:D002318), immune dysfunction (MESH:D007154), end-stage heart failure (MESH:D007676), Post (MESH:D000094025), ischemic injury (MESH:D017202), ischemic stroke (MESH:D002544), lethargy (MESH:D053609), cocaine use disorder (MESH:D019970), brain injury (MESH:D001930), brain lesions (MESH:D001927), neurologic injury (MESH:D020196), HIV (MESH:D015658), hydrocephalus (MESH:D006849), hypoxic-ischemic injury (MESH:D020925), Neurologic deterioration (MESH:D009422), systolic heart failure (MESH:D054143), Cerebellar Infarction (MESH:D007238), Heart Failure (MESH:D006333), coronary artery disease (MESH:D003324), cardiac instability (MESH:D006331)
- **Chemicals:** Substance (MESH:C012600), oxygen (MESH:D010100), norepinephrine (MESH:D009638), Cocaine (MESH:D003042), milrinone (MESH:D020105)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12967788/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12967788/full.md

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Source: https://tomesphere.com/paper/PMC12967788