# An Unexpected Cause of Diabetic Foot Ulcer Infection: Pasteurella multocida

**Authors:** Jesse H Wu, Paul M Shaniuk

PMC · DOI: 10.7759/cureus.103107 · Cureus · 2026-02-06

## TL;DR

A rare case of diabetic foot ulcer infection caused by Pasteurella multocida is reported, highlighting the importance of considering atypical pathogens and exposure history.

## Contribution

This paper presents a rare clinical case of Pasteurella multocida osteomyelitis in a diabetic patient, emphasizing its potential severity and diagnostic implications.

## Key findings

- Pasteurella multocida can cause severe osteomyelitis in diabetic foot ulcers.
- The infection likely originated from indirect exposure to a household dog.
- Culture-guided therapy and amputation were necessary for effective treatment.

## Abstract

Diabetic foot infection (DFI) is a common complication of diabetes mellitus and a major cause of preventable morbidity and mortality in individuals with diabetes. Superficial DFI can lead to contiguous spread to soft tissue and bone as well as hematogenous spread and sepsis. It frequently involves typical pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa, or it may be polymicrobial, involving Gram-negative bacilli and anaerobes. Atypical organisms can also be responsible, especially when environmental exposures are present. We report a rare case of Pasteurella multocida osteomyelitis in a 75-year-old man with diabetes with a chronic foot ulcer. The infection likely developed from indirect exposure to his household dog after a piece of dog food became trapped in his shoe, which went undetected due to peripheral neuropathy. After failing outpatient management, he presented with worsening foot swelling, erythema, and purulence and was admitted for intravenous antibiotics. His clinical status stabilized, and antibiotics were narrowed after the culture results, but ultimately, he was recommended to undergo a below-the-knee amputation. Amputation was done for definitive source control, and the patient had an uncomplicated post-surgical recovery. Although Pasteurella multocida is an uncommon cause for infection, it can lead to significant morbidity and mortality, and possible hematogenous spread and sepsis. This case study highlights the importance of thorough exposure history and culture-guided therapy in DFI, and it reviews aspects of Pasteurella infections that are associated with different outcomes.

## Linked entities

- **Diseases:** diabetes mellitus (MONDO:0005015), osteomyelitis (MONDO:0005246)
- **Species:** Pasteurella multocida (taxon 747)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** edema (MESH:D004487), pulmonary disease (MESH:D008171), weakness (MESH:D018908), Diabetes (MESH:D003920), opportunistic infection (MESH:D009894), loss of proprioception (MESH:D020886), pain (MESH:D010146), dyslipidemia (MESH:D050171), Necrotic plantar heel wound (MESH:D014947), shock (MESH:D012769), diabetic skin and soft tissue infection (MESH:D018461), redness (MESH:C562718), fever (MESH:D005334), acute osteomyelitis (MESH:D000208), fatigue (MESH:D005221), osteopenia (MESH:D001851), fowl cholera (MESH:D002771), loss of sensation (MESH:D006987), benign prostatic hyperplasia (MESH:D011470), leukocytosis (MESH:D007964), necrotic ulcer (MESH:D014456), P. multocida infection (MESH:D016720), P. multocida (MESH:D002972), Foot Infections (MESH:D007239), bacteremia (MESH:D016470), chills (MESH:D023341), foot swelling (MESH:D005530), hypertension (MESH:D006973), death (MESH:D003643), Pasteurella infections (MESH:D010326), DFI (MESH:D017719), blister (MESH:D001768), neuropathy (MESH:D009422), chronic (MESH:D002908), sepsis (MESH:D018805), Infectious Diseases (MESH:D003141), purulence (MESH:D003234), foot ulcer (MESH:D016523), erythema (MESH:D004890), peripheral neuropathy (MESH:D010523), Osteomyelitis (MESH:D010019), type 2 diabetes mellitus (MESH:D003924), peripheral arterial disease (MESH:D058729), coagulase-negative staphylococci (MESH:D064726)
- **Chemicals:** Amoxicillin-clavulanate (MESH:D019980), oxygen (MESH:D010100), methicillin (MESH:D008712), chloride (MESH:D002712), vancomycin (MESH:D014640), Cl (MESH:D002713), bicarbonate (MESH:D001639), piperacillin-tazobactam (MESH:D000077725), Cr (MESH:D002857), K (MESH:D011188), Na (MESH:D012964), creatinine (MESH:D003404), povidone-iodine (MESH:D011206), beta-lactams (MESH:D047090), ampicillin-sulbactam (MESH:C035444), CO2 (MESH:D002245)
- **Species:** Canis lupus familiaris (dog, subspecies) [taxon 9615], Pseudomonas aeruginosa (species) [taxon 287], Streptococcus pyogenes (species) [taxon 1314], Felis catus (cat, species) [taxon 9685], Homo sapiens (human, species) [taxon 9606], Staphylococcus aureus (species) [taxon 1280], Corynebacterium (genus) [taxon 1716], Bos taurus (bovine, species) [taxon 9913], Pasteurella multocida (species) [taxon 747]
- **Mutations:** A1C

## Full text

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## Figures

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## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12967787/full.md

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Source: https://tomesphere.com/paper/PMC12967787