# Temporal lobe disconnection in drug-resistant epilepsy associated with hippocampal sclerosis: how I do it

**Authors:** Antonio Leocata, Roberta di Giacomo, Vittoria Nazzi, Michele Rizzi

PMC · DOI: 10.1007/s00701-026-06826-2 · Acta Neurochirurgica · 2026-03-07

## TL;DR

This paper presents a surgical technique for treating drug-resistant epilepsy with hippocampal sclerosis, focusing on minimizing complications in older patients.

## Contribution

The paper introduces a temporal lobe disconnection technique as an alternative to resective procedures for selected cases.

## Key findings

- Temporal lobe disconnection is a viable alternative to resective procedures in selected cases.
- Strategies are provided to minimize postoperative complications, especially in patients over 50 years old.

## Abstract

Epilepsy surgery is the treatment of choice for drug-resistant epilepsy associated with hippocampal sclerosis. Patients over 50 years of age have an increased risk of postoperative complications after epilepsy surgery.

The authors present an operative video demonstrating right temporal lobe disconnection in a case of hippocampal sclerosis, along with an anatomical introduction and a section providing strategies to minimize complications.

In selected cases, temporal lobe disconnection represents a viable alternative to resective procedures.

The online version contains supplementary material available at 10.1007/s00701-026-06826-2.

## Linked entities

- **Diseases:** epilepsy (MONDO:0005027)

## Full-text entities

- **Diseases:** subdural collections (MESH:D002292), Posterior Cerebral Artery (MESH:D020762), vascular injury (MESH:D057772), cerebral infarctions (MESH:D002544), AMTL (MESH:D020232), Epilepsy (MESH:D004827), hippocampal sclerosis (MESH:D000092223), Seizure Medication (MESH:D012640), lobe disconnection (MESH:D000080422), drug-resistant epilepsy (MESH:D000069279), subdural or intracerebral hematomas (MESH:D006408), SAH (MESH:D004828), Contralateral superior quadrantanopia (MESH:D006423), cerebral atrophy (MESH:D001284), TLD (MESH:D004833), hygroma (MESH:D018191), hematoma (MESH:D006406)
- **Chemicals:** Anti (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12967433/full.md

## References

3 references — full list in the complete paper: https://tomesphere.com/paper/PMC12967433/full.md

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Source: https://tomesphere.com/paper/PMC12967433