# See, Touch, Feel, and Express: Achieving Safe and Natural Outcomes With HA Fillers—An International Consensus

**Authors:** Atchima Suwanchinda, Hosung Choi, Niamh Corduff, Haiyan Cui, Lindsay Gail Torralba Garcia, Martina Kerscher, Ting Song Lim, Olivia Ong, Je‐Young Park, Danai Praditsuwan, Tuck Wah Siew, Fang‐Wen Tseng, Raymond Wu, Tatjana Pavicic

PMC · DOI: 10.1111/jocd.70784 · Journal of Cosmetic Dermatology · 2026-03-07

## TL;DR

Experts propose a framework to achieve safe and natural results with hyaluronic acid fillers by considering multiple dimensions beyond just appearance.

## Contribution

The paper introduces a multidimensional Natural Outcomes Framework for assessing and achieving natural HA filler results.

## Key findings

- Natural outcomes involve visual, tactile, experiential, and expressive dimensions.
- Product, patient, and injector factors influence natural outcomes.
- A clinical workflow was developed to guide safe and natural HA filler treatments.

## Abstract

The concept of “natural outcomes” in filler treatments has been explored in clinical studies and literature, yet remains loosely defined, subjective, and lacks standardized assessment criteria.

To propose a multidimensional Natural Outcomes Framework to systematically define, assess, and communicate natural outcomes following hyaluronic acid (HA) filler treatment, facilitating attainment of desired results.

An international aesthetic multidisciplinary panel developed consensus statements and a practical framework for achieving safe and natural outcomes with HA fillers based on insights from a literature review, survey, and expert meeting.

This expert consensus emphasizes safety as a foundational aspect of natural outcomes. The framework extends beyond visual outcomes (“See”) to encompass tactile (“Touch”), experiential (“Feel”) and expressive (“Express”) dimensions of naturalness, which can be assessed by various methods. The panel identified three categories of factors affecting natural outcomes: product, patient, and injector factors. Treatment can be optimized by selecting HA fillers with biomimetic design, suitable rheological properties, and low inflammatory potential; ensuring knowledge and technical competency; individualizing treatment plans; and fostering effective communication. A practical clinical workflow was devised to guide the attainment and assessment of safe and natural outcomes from pre‐treatment to follow‐up.

The Natural Outcomes Framework offers a structured approach to achieving safe and desired outcomes with HA fillers, aligned with this principle: “treat the patient, not the photograph.” It promotes patient‐practitioner alignment on treatment goals and use of appropriate products based on biomimetic design principles, contributing to the attainment of predictable and satisfying results with aesthetic HA filler treatments.

## Full-text entities

- **Genes:** FOS (Fos proto-oncogene, AP-1 transcription factor subunit) [NCBI Gene 2353] {aka AP-1, C-FOS, p55}
- **Diseases:** BDD (MESH:D057215), DIRs (MESH:D018746), facial overfilled syndrome (MESH:D005156), psychiatric condition (MESH:D001523), Swelling (MESH:D004487), inflammation (MESH:D007249), skin necrosis (MESH:D012871), vascular occlusion (MESH:D008641), GAIS (MESH:C538175), granulomas (MESH:D006099), CPM (MESH:C535501)
- **Chemicals:** HA (MESH:D006820), water (MESH:D014867), BDDQ (-)
- **Species:** Sus scrofa (pig, species) [taxon 9823], Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12967260/full.md

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12967260/full.md

## References

27 references — full list in the complete paper: https://tomesphere.com/paper/PMC12967260/full.md

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Source: https://tomesphere.com/paper/PMC12967260