# Predictive value of TRIB3 combined with BMPR2 for major adverse cardiovascular events in elderly coronary heart disease patients undergoing percutaneous coronary intervention

## TL;DR

This study shows that TRIB3 and BMPR2 levels in blood can help predict heart problems in elderly patients after a common heart procedure.

## Contribution

The novel contribution is demonstrating that combining TRIB3 and BMPR2 measurements improves prediction of adverse heart events after PCI in elderly patients.

## Key findings

- TRIB3 levels were higher in CHD patients and decreased after treatment.
- BMPR2 levels were lower in CHD patients and increased after treatment.
- Combined TRIB3 and BMPR2 detection showed high sensitivity and specificity for predicting MACE.

## Abstract

This research aims to explore the correlation of Tribbles Pseudo kinase 3 (TRIB3) and bone morphogenetic protein receptor type 2 (BMPR2) with coronary heart disease (CHD), as well as the evaluation value of the combined detection of the two for major adverse cardiovascular events (MACE) following percutaneous coronary intervention (PCI).

The study enrolled 152 CHD patients (CHD group) who underwent PCI treatment between January 2023 and May 2024 and 136 healthy individuals (control group) who concurrently underwent physical examination in our hospital. The expressions of TRIB3 and BMPR2 in the serum of both groups were measured. The clinical implications of these two factors in CHD and their diagnostic value for CHD were then analysed. Subsequently, the CHD patients were subjected to a 6-month follow-up. During this period, the occurrence of MACE was recorded, and the evaluation value of the combined detection of TRIB3 and BMPR2 for MACE was analysed.

In the CHD group, the concentration of TRIB3 was significantly elevated compared to the control group, with a notable decline in TRIB3 levels after treatment (P< 0.05). In contrast, the level of BMPR2 in the CHD group was significantly lower than that of the control group, and it increased substantially following treatment (P< 0.05). In the CHD group, TRIB3 and BMPR2 were closely correlated with cardiac troponin I (cTnI) and left ventricular ejection fraction (LVEF) (P< 0.05). The combined detection of TRIB3 and BMPR2 had a diagnostic sensitivity of 76.32% and a specificity of 91.18% for CHD (P< 0.05). The follow-up results showed that 25 patients experienced MACE. The diagnostic sensitivity and specificity of the combined detection of TRIB3 and BMPR2 for MACE were 60.00% and 90.55% , respectively (P< 0.05).

TRIB3 and BMPR2 demonstrated excellent evaluation effects on CHD and the incidence of MACE after PCI.