# The role of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in the early diagnosis of pulmonary mucoepidermoid carcinoma and their clinical significance

## TL;DR

This study explores how blood cell ratios, NLR and PLR, can help diagnose pulmonary mucoepidermoid carcinoma early and reliably.

## Contribution

The study demonstrates that NLR and PLR can serve as non-invasive diagnostic indicators for PMEC.

## Key findings

- NLR and PLR levels were significantly higher in PMEC patients compared to healthy controls.
- ROC curve analysis confirmed the diagnostic potential of NLR and PLR for PMEC detection.

## Abstract

Pulmonary mucoepidermoid carcinoma (PMEC) is often misdiagnosed due to the lack of specificity of clinical symptoms. The ratio of neutrophil/lymphocyte ratio (NLR) and the ratio of platelet/lymphocyte ratio (PLR) are used in the diagnosis and prognostic assessment of a variety of diseases. This paper aims to verify the auxiliary diagnostic value of NLR and PLR in the peripheral blood of PMEC, and calculate several indices to confirm the reliability of the hypothesis.

A total of 26 patients with PMEC were enrolled as the case group, and 156 healthy patients were selected as the control group in this study according to the inclusion criteria and exclusion criteria. All clinical data were collected, and all subjects took blood from their fasting veins. The correlation analysis of NLR, PLR and tumour indicators was consistent with the normal distribution using Pearson analysis. The receiver operating characteristic (ROC) curve was used to calculate the diagnostic value of NLR and PLR.

NLR and PLR levels were significantly increased in patients with PMEC compared with healthy controls. PLR was positively correlated with the patient's stage, and NLR was independent of the patient's stage in PMEC patients. NLR was positively correlated with the patient's tumour size, and PLR was independent of the patient's tumour size. ROC curve analysis showed that NLR and PLR could be used as diagnostic indicators to distinguish patients with PMEC from normal people.

NLR and PLR tests are simple, non-invasive, inexpensive, and have high patient compliance. As potential markers for screening PMEC patients, NLR and PLR have auxiliary value for further exploration and research, and are worth promoting in the clinical setting.