# Relationship between advanced glycation end-products, serum carnosinase-1 and diabetic nephropathy and diabetic retinopathy

## TL;DR

This study found that higher levels of AGEs and CN-1 are linked to diabetic kidney and eye diseases, suggesting they could help in diagnosis and treatment.

## Contribution

Identifies AGEs and CN-1 as independent risk factors for diabetic nephropathy and retinopathy.

## Key findings

- Serum AGEs and CN-1 levels were significantly higher in patients with diabetic nephropathy and retinopathy.
- AGEs and CN-1 showed a positive correlation with the occurrence of diabetic microvascular complications.
- AGEs and CN-1 were confirmed as independent risk factors for diabetic nephropathy and retinopathy.

## Abstract

This article analysed the relationship between serum advanced glycation end-products (AGEs), carnosinase-1 (CN-1) and diabetic nephropathy (DN) and diabetic retinopathy (DR).

150 patients with type 2 diabetes mellitus (DM2) were grouped: DN and non-DN, DR and non-DR groups. Fasting venous blood was collected, and serum levels of AGEs and CN-1 were detected. Pearson's correlation (PC) test was adopted to analyse their correlation with DN and DR, and multivariate logistic regression (MLR) analysis was adopted.

There were 48 DN cases, 102 non-DN cases, 20 DR cases, and 130 non-DR cases in 150 patients with DM2. As against the non-DN group, the serum levels of AGEs and CN-1 in the subjects with DN were markedly increased. Similarly, the serum levels of AGEs and CN-1 in subjects with DR were also significantly increased compared to the non-DR group. The results of correlation analysis revealed that the levels of serum AGEs and CN-1 were positively correlated with the occurrence of DN and DR. Serum AGEs and CN-1 levels were identified as independent risk factors (IRF) for DN and DR (all P< 0.05).

AGEs and CN-1 may become new targets for the diagnosis and treatment of diabetic microvascular complications.