# Cutaneous Perineurioma of the Medial Superciliary Arch: An Uncommon Location for a Rare, Benign Spindle Cell Neoplasm

**Authors:** Sri Naidnur, Valeria González-Molina, Kara Asbury, Emily DeSantis, Rick Lin

PMC · DOI: 10.7759/cureus.103023 · Cureus · 2026-02-05

## TL;DR

A rare, benign tumor called cutaneous perineurioma was found in an unusual facial location, emphasizing the need for accurate diagnosis to prevent unnecessary treatment.

## Contribution

This case adds to the limited literature on cutaneous perineuriomas in uncommon facial locations.

## Key findings

- The tumor was located in the medial superciliary arch, a rare site for cutaneous perineurioma.
- Histological and immunophenotypic analysis confirmed the diagnosis of a benign spindle cell neoplasm.
- The case underscores the importance of recognizing this tumor to avoid misdiagnosis and overtreatment.

## Abstract

Cutaneous perineuriomas are rare, benign peripheral nerve sheath tumors that are often mistaken for other adnexal or spindle cell lesions, with facial involvement being uncommon. Recognition is important to ensure accurate diagnosis and avoid unnecessary overtreatment.

We report a case of a 36-year-old Hispanic woman with a slowly enlarging papule of the left medial superciliary arch, histologically and immunophenotypically confirmed as a cutaneous perineurioma. This case highlights the clinicopathologic features, immunohistochemical profile, and management considerations of cutaneous perineurioma arising in a rare, cosmetically sensitive facial location, adding to the limited body of published cases.

## Full-text entities

- **Genes:** SMN1 (survival of motor neuron 1, telomeric) [NCBI Gene 6606] {aka BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3}, CD34 (CD34 molecule) [NCBI Gene 947], MME (membrane metalloendopeptidase) [NCBI Gene 4311] {aka CALLA, CD10, CMT2T, NEP, SCA43, SFE}, S100A1 (S100 calcium binding protein A1) [NCBI Gene 6271] {aka S100, S100-alpha, S100A}, MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}, MLANA (melan-A) [NCBI Gene 2315] {aka MART-1, MART1}
- **Diseases:** inflammatory (MESH:D007249), melanocytic lesions (MESH:D009508), trauma (MESH:D014947), hyperpigmentation (MESH:D017495), melanocytic, and fibrohistiocytic neoplasms (MESH:D009369), amelanotic melanoma (MESH:D018328), schwannomas (MESH:D009442), adnexal or fibrohistiocytic lesions (MESH:D000291), Benign Spindle Cell Neoplasm (MESH:D002277), lymphadenopathy (MESH:D008206), Cutaneous perineuriomas (MESH:D018317), hidrocystoma (MESH:D018251), dermatofibrosarcoma protuberans (MESH:D018223), dermatofibromas (MESH:D018219), pyogenic granuloma (MESH:D017789), Schwann cell-derived tumors (MESH:C536408), papule (MESH:D000169), cell lesions (MESH:D009081), benign cutaneous lesions (MESH:D001932), solitary fibrous tumors (MESH:D054364), neurofibroma (MESH:D009455)
- **Chemicals:** H&amp;E (MESH:D006371), hematoxylin (MESH:D006416), eosin (MESH:D004801)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12967097/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12967097/full.md

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Source: https://tomesphere.com/paper/PMC12967097