# Efficacy of Lidocaine Infusion in the Management of Chronic Myofascial Pain and Intractable Migrainous Headache in a Patient With Hypermobile Ehlers-Danlos Syndrome: A Case Report

## TL;DR

A patient with hypermobile Ehlers-Danlos Syndrome experienced significant pain relief from lidocaine treatments, including injections and infusions.

## Contribution

Demonstrates the efficacy of lidocaine-based therapies for managing chronic pain in hypermobility-related disorders.

## Key findings

- Trigger-point injections provided over 50% myofascial pain relief for more than one month.
- Intravenous lidocaine infusion resulted in extended and widespread pain relief.
- Lidocaine-based therapies improved clinical outcomes in a complex hypermobility-related pain syndrome.

## Abstract

Hypermobile Ehlers-Danlos Syndrome (hEDS) is the most common type of inherited connective tissue disorder, often presenting with chronic widespread myofascial pain, autonomic dysfunction, soft-tissue fragility, and psychiatric comorbidities. Pain is often multifactorial and refractory to conventional therapies. We describe a young adult with longstanding hypermobility, recurrent subluxations, chronic periscapular pain, migrainous headaches, and dysautonomia who achieved marked clinical improvement with lidocaine-based therapies, including trigger-point injections (TPIs) and scheduled intravenous lidocaine infusion. TPIs provided more than 50% relief of the myofascial pain for over one month, which is significantly longer than the typical duration of conservative treatments. A lidocaine infusion was subsequently administered to provide extended and more widespread pain relief, resulting in a favorable clinical outcome. This case illustrates the value of lidocaine as part of a multimodal strategy in managing complex hypermobility-related pain syndromes.