# Prevalence and associated factors for COPD and pre-COPD in Guizhou Province, China: A cross-sectional study

**Authors:** Songjun Shao, Silu Hu, Cheng Zhang, Shan S. Rao, Guohang Yuan, Xiaoju Tang, Xianwei Ye

PMC · DOI: 10.18332/tid/215242 · Tobacco Induced Diseases · 2026-03-06

## TL;DR

This study finds that COPD and pre-COPD are common in Guizhou, China, linked to smoking, indoor pollution, and low education.

## Contribution

The study provides new prevalence data and risk factors for COPD and pre-COPD in Guizhou Province, China.

## Key findings

- The overall prevalence of COPD was 9.60% and pre-COPD was 8.92% in Guizhou.
- Smoking, indoor smoke exposure, and low education were significant risk factors.
- Indoor biomass burning contributed to 3.24% of smoke exposure in participants.

## Abstract

In China, the incidence of chronic obstructive pulmonary disease (COPD) is escalating swiftly, encompassing almost 100 million patients documented in 2018. Nevertheless, a considerable proportion of individuals persist in a Pre-COPD condition and have not been given a COPD diagnosis. Currently, the prevalence of COPD and Pre-COPD, linked to various associated factors in Guizhou Province, China, is still uncertain.

Adults aged ≥20 years were enrolled in a 2012 cross-sectional survey of Guizhou Province via multistage random sampling. All participants underwent post-bronchodilator pulmonary function tests (PFTs). The 2012 Global Initiative for COPD was used for diagnosis.

The participants were 6400, recruited in Guizhou Province, of whom 5395 provided reliable post-bronchodilator results and were included in the final analysis. Among individuals aged ≥20 years, the overall prevalence of COPD was 9.60%, and of Pre-COPD was 8.92%. The important factors associated with COPD and Pre-COPD included smoking, household smoke pollution, and low level of education. This survey revealed that 31.96% of participants had a history of smoking, and 3.30% had successfully quit smoking. Indoor smoke exposure from biomass burning contributed to 3.24% of the total biomass. Additionally, a lower level of education was identified as a significant associated factor for COPD and Pre-COPD.

In Guizhou, COPD and Pre-COPD prevalence are greater than those in the general Chinese population. The primary associated factors for COPD and Pre-COPD include smoking (especially mother smoking during pregnancy), exposure to kitchen cooking fumes, and low level education.

## Linked entities

- **Diseases:** chronic obstructive pulmonary disease (MONDO:0005002), COPD (MONDO:0005002)

## Full-text entities

- **Genes:** CYGB (cytoglobin) [NCBI Gene 114757] {aka HGB, NOD, STAP}, FGB (fibrinogen beta chain) [NCBI Gene 2244] {aka HEL-S-78p}
- **Diseases:** lung development (MESH:D002658), airway dysfunction (MESH:D000402), TB (MESH:D014390), retinal detachment (MESH:D012163), pulmonary heart disease (MESH:D011660), depression (MESH:D003866), tuberculosis (MESH:D014376), pneumonia (MESH:D011014), Chronic Obstructive Lung Disease (MESH:D029424), Pre (MESH:D058246), damage to the lungs (MESH:D008171), chronic bronchitis (MESH:D029481), cancer (MESH:D009369), myocardial infarction (MESH:D009203), bronchitis (MESH:D001991), lung cancer (MESH:D008175), infections (MESH:D007239), PRISm (MESH:C537758), asthma (MESH:D001249), emphysema (MESH:D004646), anxiety (MESH:D001007), cough (MESH:D003371), GERD (MESH:D005764), respiratory tract infections (MESH:D012141), bronchiectasis (MESH:D001987), death (MESH:D003643)
- **Species:** Nicotiana tabacum (American tobacco, species) [taxon 4097], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12966984/full.md

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Source: https://tomesphere.com/paper/PMC12966984