# Analysis of factors influencing weight regain after bariatric-metabolic surgery in obesity hypoventilation syndrome patients based on gastrointestinal peptide hormones

## TL;DR

This study examines how gastrointestinal hormones and lifestyle factors affect weight regain in patients with obesity hypoventilation syndrome after bariatric surgery.

## Contribution

The study identifies specific gastrointestinal peptide hormones and lifestyle factors as predictors of weight regain after bariatric surgery in OHS patients.

## Key findings

- Levels of INS, Lep, and GLP-1 increased while ghrelin decreased after surgery.
- Unfavorable diet, lack of exercise, trace element deficiencies, and negative emotions were independent risk factors for weight regain.
- Gastrointestinal peptide hormones showed strong predictive value for postoperative weight regain.

## Abstract

Obesity is becoming increasingly prevalent in modern society, leading to a rise in the incidence of obesity hypoventilation syndrome (OHS). This study analyzes the factors influencing weight regain in OHS patients following laparoscopic sleeve gastrectomy (LSG), based on gastrointestinal peptide hormones.

A total of 134 OHS patients who underwent LSG at our hospital between January 2023 and January 2024 were enrolled. The alterations in gastrointestinal peptide hormones, including insulin (INS), leptin (Lep), glucagonlike peptide-1 (GLP-1), and ghrelin (GHR), before and after surgery were measured. Subsequently, a 6-month followup was conducted. Patients with weight regain were identified, and the predictive value of gastrointestinal peptide hormones for weight regain was analyzed. Logistic regression was then employed to analyze the related factors affecting weight regain.

Following the surgical procedure, a significant increase was observed in the levels of INS, Lep, and GLP accompanied by a notable decrease in GHR levels among the patients (P < 0.05). During the follow-up period, 32 patients experienced weight regain. The receiver operating characteristic (ROC) curve analysis demonstrated that gastrointestinal peptide hormones exhibited outstanding predictive capabilities for postoperative weight regain. Moreover, through statistical analysis, it was determined that unfavorable dietary habits, lack of regular exercise, trace element deficiencies, and negative emotional states were independent risk factors influencing weight regain following LSG (P < 0.05).

There is a close correlation between gastrointestinal peptide hormones and post-LSG weight alterations in patients with OHS.