# Joint effusion after anterior cruciate ligament reconstruction: Associations with higher postoperative physical activity, patella alta and increased quadriceps tension

**Authors:** Jiebin Huang, Bin Song, Guohui Lin, Zilong He, Congda Zhang, Siu Ngor Fu

PMC · DOI: 10.1002/jeo2.70678 · Journal of Experimental Orthopaedics · 2026-03-07

## TL;DR

This study finds that higher physical activity and patella alta after ACL surgery are linked to joint effusion, and residual effusion is associated with increased quadriceps tension over time.

## Contribution

The study identifies novel associations between postoperative physical activity, patellar alignment, and quadriceps tension with joint effusion after ACL reconstruction.

## Key findings

- Higher postoperative physical activity is associated with increased joint effusion at 3 and 24 months post-ACLR.
- Greater patella alta (Insall-Salvati ratio) is linked to higher effusion grades at 12 months and beyond.
- Residual effusion correlates with increased quadriceps tension during isometric contractions after one year.

## Abstract

(1) To explore postoperative factors associated with effusion after anterior cruciate ligament reconstruction (ACLR), and (2) to investigate the associations between effusion and quadriceps tension and activation across rehabilitation and return‐to‐sport (RTS) phases.

In this cross‐sectional study, participants were assessed at approximately 3, 6, 12 and ~24 months post‐ACLR and further analysed by phase (3–6 vs. 12–24 months). Effusion (Anterior Cruciate Ligament Osteoarthritis Score [ACLOAS]) and patellar alignment (Insall‐Salvati ratio [ISR], bisect offset [BO], patellar tilt angle [PTA]) were quantified by 3.0‐T magnetic resonance imaging. Quadriceps tension and activation were quantified by shear wave elastography (SWE) and surface electromyography (EMG) during resting and isometric knee extension conditions. Physical activity was assessed using The International Physical Activity Questionnaire‐Short Form (IPAQ‐SF). Ordinal logistic regression tested associations with effusion; generalised linear models evaluated relationships between effusion and muscle outcomes (α = 0.05).

A total of 119 participants (75% male, age 29 ± 6 years) who underwent single‐bundle ACLR with hamstring tendon autograft were included in this study. Higher postoperative physical activity (MET‐min/week) was associated with higher effusion grade at 3‐month (odds ratio [OR] = 1.07, p < 0.01) and 24‐month (OR = 1.05, p = 0.05) groups; greater ISR was associated with higher effusion grade at ≥12 months (OR = 1.08, p < 0.01). Higher effusion grade was associated with higher vastus medialis and lateralis shear modulus at ≥12 months (B = 7–11 kPa, all p < 0.04) during the isometric knee extension condition; No association was observed for normalised EMG activation (all p > 0.09).

Postoperative activity and patella alta were associated with joint effusion after ACLR. Additionally, residual effusion was associated with higher quadriceps tension under submaximal contraction beyond 1 year. These findings suggest that phase‐specific monitoring of physical activity and patellofemoral joint loading may benefit joint health and knee function after ACLR.

Level IV.

## Full-text entities

- **Genes:** TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, MLC1 (modulator of VRAC current 1) [NCBI Gene 23209] {aka LVM, MLC, VL}
- **Diseases:** muscle (MESH:D019042), muscle tension (MESH:D018781), inflammatory (MESH:D007249), asymmetric loading (MESH:C536761), swelling (MESH:D004487), ACL injury (MESH:D000070598), joint irritation (MESH:D001523), aneurysm (MESH:D000783), quadriceps weakness (MESH:D018908), muscle fatigue (MESH:D005221), impingement (MESH:D019534), GLM (MESH:D004195), knee pain (MESH:D046788), Patellar malalignment (MESH:D017760), cartilage lesion (MESH:D002357), Osteoarthritis (MESH:D010003), knee injuries (MESH:D007718), Patella alta (MESH:D000092462), meniscal injury (MESH:D010007), lateral displacement (MESH:D006617), oedema (MESH:C536897), Joint effusion (MESH:D000080324), synovial irritation (MESH:D013581), chondral degeneration (MESH:D009410), AMI (MESH:C565433), Hoffa's fat pad (MESH:D000092525), chronic effusion (MESH:C564895)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

44 references — full list in the complete paper: https://tomesphere.com/paper/PMC12966962/full.md

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Source: https://tomesphere.com/paper/PMC12966962