# A 12-year expanding pink plaque on the chest

**Authors:** Farshid Etaee, Frank Castiglione, Xingyuan Jiang, Ronghua Hu, Anjela Galan, Keith A. Choate, Matthew D. Vesely

PMC · DOI: 10.1016/j.jdcr.2025.11.058 · JAAD Case Reports · 2026-01-22

## Full-text entities

- **Genes:** MVK (mevalonate kinase) [NCBI Gene 4598] {aka LRBP, MK, MVLK, POROK3}, HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) [NCBI Gene 3156] {aka LDLCQ3, LGMDR28, MYPLG}
- **Diseases:** inherited skin disorders (MESH:D012868), itch (MESH:D011537), erythema (MESH:D004890), Giant porokeratosis (MESH:D017499), Majocchi granuloma (MESH:C569516), pain (MESH:D010146), lipid metabolism defects (MESH:D052439), porokeratosis palmaris plantaris et disseminatum (MESH:C536338), Lues maligna (MESH:D018327), premalignant disease (MESH:D004194), lymphohistiocytic inflammation (MESH:D007249), Marjolin ulcer (MESH:D014456), erosions (MESH:D014077), Bowen disease (MESH:D001913)
- **Chemicals:** retinoids (MESH:D012176), lipid (MESH:D008055), lovastatin (MESH:D008148), 5-fluorouracil (MESH:D005472), Cholesterol (MESH:D002784), imiquimod (MESH:D000077271), tacrolimus (MESH:D016559), mevalonate (MESH:D008798)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** C643T, p.R215*, p.S145F, C434T

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## Figures

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## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12966874/full.md

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Source: https://tomesphere.com/paper/PMC12966874