# Case of a genodermatosis presenting with verrucous lesions mimicking treatment-refractory warts

**Authors:** Raj P. Fadadu, Charisse Orme

PMC · DOI: 10.1016/j.jdcr.2026.01.036 · JAAD Case Reports · 2026-02-02

## Full-text entities

- **Genes:** CD8A (CD8 subunit alpha) [NCBI Gene 925] {aka CD8, CD8alpha, IMD116, Leu2, p32}, MTOR (mechanistic target of rapamycin kinase) [NCBI Gene 2475] {aka FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) [NCBI Gene 5295] {aka AGM7, GRB1, IMD36, p85, p85-ALPHA, p85alpha}, PTEN (phosphatase and tensin homolog) [NCBI Gene 5728] {aka 10q23del, BZS, CWS1, DEC, GLM2, MHAM}, CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}
- **Diseases:** Arsenic keratoses (MESH:D007642), soft tissue tumors (MESH:D012983), T-cell lymphopenia (MESH:D008231), keloids (MESH:D007627), verrucous keratosis (MESH:D018289), cancer (MESH:D009369), infections (MESH:D007239), neurocognitive delay (MESH:D019965), colon cancer (MESH:D015179), skin involvement (MESH:D012871), myelokathexis (WHIM) syndrome (MESH:C536697), Bannayan-Riley-Ruvalcaba syndrome (MESH:D006223), immunodeficiency (MESH:D007153), Warts (MESH:D014860), melanoma (MESH:D008545), colon, endometrial, breast, kidney, and thyroid (MESH:C537262), natural killer-cell immunodeficiency (MESH:D000077428), immune dysregulation (OMIM:614878), vascular malformations (MESH:D054079), papules (MESH:D000169), hypogammaglobulinemia (MESH:D000361), papillomatosis lesions (MESH:D010212), Epidermodysplasia verruciformis (MESH:D004819), sclerotic fibromas (MESH:D005350), macrocephaly (MESH:D058627), skeletal abnormalities (MESH:D009139)
- **Chemicals:** sirolimus (MESH:D020123), salicylic acid (MESH:D020156), 5-flourouracil (-), imiquimod (MESH:D000077271)
- **Species:** Homo sapiens (human, species) [taxon 9606], Human immunodeficiency virus 1 (no rank) [taxon 11676]
- **Mutations:** p.Arg335*, c.1003C>T

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## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12966864/full.md

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Source: https://tomesphere.com/paper/PMC12966864