# Early experience with a composite ovine forestomach matrix graft in chronic lower extremity wounds: a multi-center retrospective case series

## TL;DR

A new outpatient treatment using a composite bioscaffold with ovine forestomach matrix and hyaluronic acid showed effectiveness and safety in healing chronic lower extremity wounds.

## Contribution

This study presents early evidence of a novel composite bioscaffold (OFM-HA) for treating chronic lower extremity wounds in an outpatient setting.

## Key findings

- The mean time to 50% wound area reduction was 3.2 weeks, and mean time to full closure was 9.9 weeks.
- OFM-HA was applied a median of 4 times with no complications or recurrences observed.
- The bioscaffold proved durable and effective for complex chronic wounds in elderly patients with comorbidities.

## Abstract

Chronic wounds place a significant burden on patients and healthcare. A newer outpatient treatment is a composite bioscaffold that contains ovine forestomach matrix and hyaluronic acid (OFM-HA). This multi-center retrospective case series investigated OFM-HA in the treatment of lower extremity chronic wounds. Medical records of 10 patients were reviewed and patient and wound characteristics were documented. Time to 50% percent area reduction (%PAR), time to closure, and complications were evaluated. Patients were primarily elderly with several comorbidities. The mean time to 50% PAR was 3.2 ± 2.3 weeks, and the mean time to closure was 9.9 ± 5.1 weeks. Patients received a median of 4 (IQR: 2, 5) applications. No complications or recurrences occurred. OFM-HA was effective and safe to treat complex lower extremity chronic wounds in the outpatient setting. Moreover, OFM-HA proved to be a durable material, with full closure requiring few applications.