# Ectopic adrenal tissue in the mesosalpinx: a rare incidental finding in an adult woman

**Authors:** Behrooz Shokouhi, Ali Kazemiathar

PMC · DOI: 10.1093/jscr/rjag071 · Journal of Surgical Case Reports · 2026-03-07

## TL;DR

A rare case of ectopic adrenal tissue was found in the mesosalpinx of an adult woman during a routine surgical procedure.

## Contribution

This case report highlights the exceptional occurrence of adrenal cortical rests in the mesosalpinx of an adult female.

## Key findings

- Ectopic adrenal tissue was identified in the left mesosalpinx of a 47-year-old woman.
- The tissue formed a 3-mm nodule with features consistent with adrenal cortex.
- The case emphasizes the importance of thorough histopathological examination for rare developmental anomalies.

## Abstract

Ectopic adrenal tissue is most often identified incidentally on histopathological examination. It is reported mainly in male children and is usually located within the abdominopelvic cavity. Although adrenal cortical rests have been described in the female genital tract, involvement of the mesosalpinx (paratubal region) is exceptionally rare. We report a microscopic adrenal cortical rest in the left mesosalpinx of a 47-year-old woman who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for abnormal uterine bleeding and evaluation of bilateral complex ovarian cysts. The ectopic rest formed a well-circumscribed 3-mm nodule composed of bland polygonal cells with clear to eosinophilic cytoplasm, consistent with adrenal cortex. This case underscores the value of careful gross sampling and microscopic review in detecting uncommon developmental anomalies that are clinically silent.

## Full-text entities

- **Genes:** MLANA (melan-A) [NCBI Gene 2315] {aka MART-1, MART1}, SYP (synaptophysin) [NCBI Gene 6855] {aka MRX96, MRXSYP, XLID96}, SF1 (splicing factor 1) [NCBI Gene 7536] {aka BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162}, NR5A1 (nuclear receptor subfamily 5 group A member 1) [NCBI Gene 2516] {aka AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1}, CALB2 (calbindin 2) [NCBI Gene 794] {aka CAB29, CAL2, CR}
- **Diseases:** ectopic adrenal cortex (MESH:D000303), serous cystadenomas (MESH:D018293), clear cell renal cell carcinoma (MESH:D002292), ectopic (MESH:C566852), tissue (MESH:D017695), hyperplasia (MESH:D006965), malignancy (MESH:D009369), ectopic adrenal cortical tissue (MESH:D002828), necrosis (MESH:D009336), adrenal hormone excess (MESH:C531600), myomatous uterus (MESH:D014594), benign ectopic adrenal rest (MESH:D000314), Sertoli-Leydig cell tumor (MESH:D018310), endometrial polyp (MESH:D014591), xanthomatous inflammation (MESH:D007249), paraganglioma (MESH:D010235), ovarian cysts (MESH:D010048), leiomyomas (MESH:D007889), developmental anomalies (MESH:C566440), bleeding (MESH:D006470), vaginal bleeding (MESH:D014592)
- **Chemicals:** eosin (MESH:D004801), lipid (MESH:D008055), Hematoxylin (MESH:D006416), H&amp;E (MESH:D006371)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12966784/full.md

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Source: https://tomesphere.com/paper/PMC12966784