# Gallbladder tuberculosis as an incidental calcified mass in an elderly male: a case report

**Authors:** Ho Tran, Kim H Nguyen, Thanh P C Nguyen, Phuoc T Bui

PMC · DOI: 10.1093/jscr/rjag123 · Journal of Surgical Case Reports · 2026-03-07

## TL;DR

An elderly man with a history of tuberculosis had a calcified gallbladder mass that was initially suspected to be cancer but was later diagnosed as gallbladder tuberculosis.

## Contribution

This case highlights gallbladder tuberculosis as a rare but important differential diagnosis for calcified gallbladder masses.

## Key findings

- A calcified gallbladder mass was found in a patient with a history of tuberculosis.
- Histopathology confirmed the mass was due to gallbladder tuberculosis, not cancer.
- The patient underwent successful cholecystectomy and was treated for tuberculosis.

## Abstract

Gallbladder tuberculosis (GBT) is exceptionally rare and may closely mimic gallbladder carcinoma. We report a 71-year-old male with a history of successfully treated pulmonary tuberculosis who was asymptomatic and incidentally found on screening ultrasonography to have a calcified mass at the gallbladder fundus. Contrast-enhanced computed tomography (CT) demonstrated a 2 × 4 cm calcified fundal lesion with focal wall thickening, raising strong suspicion of malignancy. Laparoscopic cholecystectomy with intraoperative frozen section was performed. Despite severe inflammatory adhesions suggestive of invasive cancer, frozen section and final histopathology confirmed caseating granulomatous inflammation consistent with GBT, and surgery was limited to simple cholecystectomy. The postoperative course was uneventful, and the patient was referred for antituberculous therapy. GBT should be considered in the differential diagnosis of calcified gallbladder masses to avoid overtreatment.

## Linked entities

- **Diseases:** tuberculosis (MONDO:0018076), gallbladder carcinoma (MONDO:0003220)

## Full-text entities

- **Genes:** CEACAM3 (CEA cell adhesion molecule 3) [NCBI Gene 1084] {aka CD66D, CEA, CGM1, CGM1a, W264, W282}, AFP (alpha fetoprotein) [NCBI Gene 174] {aka AFPD, FETA, HPAFP}
- **Diseases:** cystic duct obstruction (MESH:D018297), pain (MESH:D010146), pulmonary lesions (MESH:D008171), tuberculous calcified lesion (MESH:D014390), jaundice (MESH:D007565), fever (MESH:D005334), cholelithiasis (MESH:D002769), gallbladder carcinoma (MESH:D005706), granulomatous (MESH:D013968), anorexia (MESH:D000855), pulmonary tuberculosis (MESH:D014397), Hepatobiliary tuberculosis (MESH:D004066), calcified lesion (MESH:D018333), Tumor (MESH:D009369), granulomas (MESH:D006099), abdominal pain (MESH:D015746), granulomatous inflammation (MESH:D007249), GBT (MESH:D014376), weight loss (MESH:D015431), Calcification of the gallbladder (MESH:D005705), Abdominal tuberculosis (MESH:D000007), gallstones (MESH:D042882), necrosis (MESH:D009336), adhesions (MESH:D000267), cholecystitis (MESH:D002764), infection (MESH:D007239)
- **Species:** Mycobacterium tuberculosis (species) [taxon 1773], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12966777/full.md

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Source: https://tomesphere.com/paper/PMC12966777