Wenyang Decoction Ameliorates DSS‐Induced Ulcerative Colitis by Regulating Macrophage Polarization and the PI3K/AKT/mTOR/HIF‐1α Signaling Pathway
Shengwei Li, Guanghui Yuan, Chan Chen, Jihong Lu, Xing Zhang
TL;DR
This study shows that Wenyang Decoction reduces symptoms of ulcerative colitis in mice by altering immune cell behavior and key signaling pathways.
Contribution
The study reveals a novel mechanism by which Wenyang Decoction treats UC through macrophage polarization and the PI3K/AKT/mTOR/HIF-1α pathway.
Findings
Wenyang Decoction reduced inflammation and improved colon health in a mouse model of UC.
The treatment suppressed M1 macrophage polarization and promoted M2 macrophage polarization.
Wenyang Decoction inhibited the PI3K/AKT/mTOR/HIF-1α signaling pathway, reducing oxidative stress and inflammation.
Abstract
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by intestinal inflammation and epithelial damage. This study aims to investigate the therapeutic effects of Wenyang decoction (WYD) in a dextran sulfate sodium (DSS)‐induced UC model and its underlying mechanisms, with a focus on macrophage polarization and the regulation of the PI3K/AKT/mTOR/HIF‐1α signaling pathway. A DSS‐induced UC model was established in C57BL/6 mice. Treatment groups received WYD at low (8.25 g/kg/day), medium (16.50 g/kg/day), or high (33.00 g/kg/day) doses, with 5‐aminosalicylic acid (5‐ASA, 200 mg/kg) as a positive control. Assessments included disease activity index (DAI), colon length, histopathology, and levels of inflammatory cytokines (IL‐1β, IL‐6, and TNF‐α) and oxidative stress markers (SOD, CAT, and MDA). Mechanisms were probed using western blot, qPCR, immunofluorescence,…
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Taxonomy
TopicsInflammatory Bowel Disease · Traditional Chinese Medicine Analysis · Immune cells in cancer