# Reprogramming Skin Aging: A Regenerative and Epigenetic Perspective on Cutaneous Longevity

**Authors:** Diala Haykal, Michael Gold, Edward Lain, Jeremy Green, Patricia K. Farris

PMC · DOI: 10.1111/jocd.70788 · 2026-03-06

## Full-text entities

- **Genes:** POMC (proopiomelanocortin) [NCBI Gene 5443] {aka ACTH, CLIP, LPH, MSH, NPP, OBAIRH}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, NFKB1 (nuclear factor kappa B subunit 1) [NCBI Gene 4790] {aka CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1}, CRH (corticotropin releasing hormone) [NCBI Gene 1392] {aka CRF, CRH1}, TGFB1 (transforming growth factor beta 1) [NCBI Gene 7040] {aka CAEND1, CED, DPD1, IBDIMDE, LAP, TGF-beta1}, PER2 (period circadian regulator 2) [NCBI Gene 8864] {aka FASPS, FASPS1}, ELN (elastin) [NCBI Gene 2006] {aka ADCL1, SVAS, WBS, WS}, NFE2L2 (NFE2 like bZIP transcription factor 2) [NCBI Gene 4780] {aka IMDDHH, NRF2, Nrf-2}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, BMAL1 (basic helix-loop-helix ARNT like 1) [NCBI Gene 406] {aka ARNTL, ARNTL1, BMAL1c, JAP3, MOP3, PASD3}, IGF1R (insulin like growth factor 1 receptor) [NCBI Gene 3480] {aka CD221, IGFIR, IGFR, JTK13}, GLB1 (galactosidase beta 1) [NCBI Gene 2720] {aka EBP, ELNR1, MPS4B}
- **Diseases:** atopic dermatitis (MESH:D003876), chronic (MESH:D002908), Cutaneous Longevity (MESH:D018366), Dysbiosis (MESH:D064806), Aging (MESH:D019588), barrier dysfunction (MESH:C536830), inflammation (MESH:D007249), SLI (MESH:D012871), rosacea (MESH:D012393)
- **Chemicals:** Cu (MESH:D003300), resveratrol (MESH:D000077185), acetate (MESH:D000085), ceramides (MESH:D002518), hyaluronic acid (MESH:D006820), SCFAs (MESH:D005232), indole (MESH:C030374), water (MESH:D014867), polyphenols (MESH:D059808), AGEs (MESH:D017127), poly-L-lactic acid (MESH:C033616), astaxanthin (MESH:C005948), amino acid (MESH:D000596), cortisol (MESH:D006854), coenzyme Q10 (MESH:C024989), propionate (MESH:D011422), calcium hydroxylapatite (MESH:D017886)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12965852/full.md

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Source: https://tomesphere.com/paper/PMC12965852