# Epithelioid Sarcoma of the Forearm in a 70‐Year‐Old Woman: A Case Report at a Referral Facility in Tanzania

**Authors:** Furaha E. Kasyupa, Jeremia J. Pyuza, Abitalis Mayengela, Agumbwike Mwakitwange, Deardiana Sengelela, Gilbert Nkya, Patrick Amsi, Angela Pallangyo, Alex Mremi

PMC · DOI: 10.1002/ccr3.72171 · 2026-03-06

## TL;DR

A rare case of epithelioid sarcoma in an elderly woman highlights the importance of accurate diagnosis and complete surgical removal for better outcomes.

## Contribution

Presents a rare case of epithelioid sarcoma in an elderly patient, emphasizing diagnostic challenges and treatment in non-typical demographics.

## Key findings

- Epithelioid sarcoma can present in elderly patients, mimicking benign lesions.
- Accurate histopathological and immunohistochemical evaluation is essential for diagnosis.
- Complete surgical excision is crucial for optimal patient outcomes.

## Abstract

Epithelioid sarcoma, though typically seen in young males, can occur in elderly patients and mimic benign lesions. Clinicians should maintain a high index of suspicion for chronic, slow‐growing extremity masses as accurate histopathological and immunohistochemical evaluation with complete surgical excision is crucial for optimal outcomes.

## Linked entities

- **Diseases:** epithelioid sarcoma (MONDO:0004105)

## Full-text entities

- **Genes:** DES (desmin) [NCBI Gene 1674] {aka CDCD3, CSM1, CSM2, LGMD1D, LGMD1E, LGMD2R}, MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}, SMN1 (survival of motor neuron 1, telomeric) [NCBI Gene 6606] {aka BCD541, GEMIN1, SMA, SMA1, SMA2, SMA3}, CD34 (CD34 molecule) [NCBI Gene 947], EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) [NCBI Gene 2146] {aka ENX-1, ENX1, EZH2b, KMT6, KMT6A, WVS}, VIM (vimentin) [NCBI Gene 7431], SMARCB1 (SWI/SNF related BAF chromatin remodeling complex subunit B1) [NCBI Gene 6598] {aka BAF47, CSS3, INI-1, INI1, MRD15, PPP1R144}
- **Diseases:** poorly differentiated (MESH:D020522), necrosis (MESH:D009336), tenderness (MESH:D063806), forearm lesion (MESH:D005543), lymph node metastasis (MESH:D008207), wound infection (MESH:D014946), soft-tissue malignancy (MESH:D012983), soft (MESH:C562950), hypertension (MESH:D006973), synovial sarcoma (MESH:D013584), metastasis (MESH:D009362), epithelial neoplasms (MESH:D009375), extremity masses (MESH:C536030), Epithelioid Sarcoma (MESH:D012509), jaundice (MESH:D007565), mesenchymal tumor (MESH:C535700), granulomatous disease (MESH:D006105), lymphadenopathy (MESH:D008206), Glomus tumor (MESH:D005918), rhabdomyosarcoma (MESH:D012208), edema (MESH:D004487), Tumor (MESH:D009369), endometrioid endometrial carcinoma (MESH:D018269), inflammatory dermatoses (MESH:D012871), granulomatous conditions (MESH:D020763), chronic inflammation (MESH:D007249), melanoma (MESH:D008545)
- **Chemicals:** Periodic Acid (MESH:D010504), urea (MESH:D014508), H&amp;E (MESH:D006371), oxygen (MESH:D010100)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12965846/full.md

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Source: https://tomesphere.com/paper/PMC12965846