Investigating the structure and bioactivity of lanthanum coordination compounds

TL;DR

This study shows that lanthanum coordination compounds have strong antimicrobial and antimalarial properties, making them promising for new drug development.

Contribution

The paper reports the synthesis and characterization of lanthanum complexes with potent antimicrobial and antimalarial activities.

Findings

Lanthanum complexes showed inhibition zones of 18–26 mm against bacteria like Staphylococcus aureus and Escherichia coli.

Antifungal activity was observed with inhibition zones of 15–23 mm against Candida albicans and Aspergillus niger.

Moderate antimalarial activity was found against Plasmodium falciparum with an IC50 of 12.4 μM.

Abstract

Lanthanum metal complexes were synthesized using a classical condensation method by reacting lanthanum nitrate salts with a bidentate ligand in a 1:2:1 molar ratio (M:L:L). The formation and structure of the resulting complexes were confirmed through a combination of analytical techniques, including Fourier transformation infrared spectroscopy, thermal gravimetric analysis, X-ray diffraction, elemental microanalysis, and scanning electron microscopy.

The lanthanum complexes synthesized exhibited strong in vitro antimicrobial activity. Antibacterial screening showed inhibition zones of 18–26 mm against Staphylococcus aureus and Escherichia coli, surpassing those of the reference drug ciprofloxacin (16–20 mm). Antifungal studies demonstrated inhibition zones of 15–23 mm against Candida albicans and Aspergillus niger. The MIC values ranged from 25 to 50 μg/mL, indicating high potency. Additionally, moderate antimalarial activity was observed against Plasmodium falciparum (IC50 = 12.4 μM).

These findings confirm that lanthanum complexes possess potent antibacterial and antifungal properties, highlighting their promise as potential candidates for novel antimicrobial and antimalarial drug development.

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