Development of nanoemulsion formulation loaded with Enteromorpha intestinalis extract: Characterization and evaluation for topical use
Shumaila Qadir, Shahlla Imam, Syed Abid Ali, Fatima Ramzan Ali, Wajiha Iffat, Rabia Ismail Yousuf, Rafia Usman, Shahana Wahid, Iqbal Azhar
TL;DR
This paper develops a nanoemulsion using green seaweed extract for topical use, showing it is stable, effective, and safe for skin application.
Contribution
The study introduces a novel nanoemulsion formulation incorporating Enteromorpha intestinalis extract for the first time.
Findings
The optimal nanoemulsion (F6) had a droplet size of 183.27 ± 20.04 nm and good skin compatibility.
The nanoemulsion showed greater antioxidant efficacy than the seaweed extract alone with an IC50 of 163.19 μg/mL.
The formulation significantly inhibited paw volume in an anti-inflammatory test and was non-irritating.
Abstract
Enteromorpha intestinalis is a green seaweed enriched with diverse bioactive compounds that possess substantial pharmacological and biotechnological properties. Despite the focus on their therapeutic applications, research on the development of nano-formulations is limited. Therefore, this study aimed to develop an E. intestinalis (EI) extract-based nanoemulsion for topical use. Olive oil, Tween-80 (surfactant), and PEG-400 (co-surfactant) were selected for the formulation of the nanoemulsion. The Smix ratio was set to 1:1 using a pseudo-ternary phase diagram. Moreover, a design experiment ascertained the composition of the formulation, followed by physicochemical characterization. The optimal formulation, based on droplet size, was selected for further analysis. Stability studies, antioxidant and anti-inflammatory properties of selected nanoemulsion formulation were determined and…
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Taxonomy
TopicsSeaweed-derived Bioactive Compounds · Proteins in Food Systems · Polysaccharides and Plant Cell Walls