# Incidental Discovery and Removal of an Appendiceal Mucocele in a Patient With Acute Cholecystitis

**Authors:** Harrison Hunter, Annabel Barber, Daman Samrao

PMC · DOI: 10.7759/cureus.102962 · 2026-02-04

## TL;DR

A rare case where a patient with gallbladder inflammation had an unexpected appendix tumor and liver lesion discovered and treated during surgery.

## Contribution

Reports a rare incidental finding and successful surgical management of an appendiceal mucocele during cholecystectomy.

## Key findings

- Appendiceal mucocele and hepatic lesion were identified during CT for acute cholecystitis.
- Surgical excision confirmed benign appendiceal mucocele and hemangioma in the liver.
- Highlights the importance of removing appendiceal mucoceles to prevent life-threatening complications.

## Abstract

Appendiceal mucoceles (AMs) are a rare clinical entity among appendiceal tumors. They are characterized by dilation of the appendix and accumulation of mucus within the lumen. These lesions are often discovered incidentally during imaging or surgery for unrelated abdominal complaints. We report a case of a 55-year-old male who presented with right upper quadrant pain due to acute cholecystitis. An AM and a hepatic lesion were incidentally identified on abdominal CT. The patient underwent a robotic-assisted laparoscopic cholecystectomy and appendectomy, with pathology confirming a benign AM and acute cholecystitis. A coincidental hepatic lesion was also biopsied and diagnosed as a hemangioma. Although rare and usually benign, AMs have the potential to rupture and cause the potentially fatal condition pseudomyxoma peritonei. They may also become malignant, act as lead points for intussusception, or cause bowel obstruction due to mass effect. This case highlights the importance of a comprehensive abdominal evaluation and demonstrates the value of prompt surgical excision of AMs to prevent complications.

## Linked entities

- **Diseases:** acute cholecystitis (MONDO:0002155), pseudomyxoma peritonei (MONDO:0017048), hemangioma (MONDO:0006500)

## Full-text entities

- **Genes:** PECAM1 (platelet and endothelial cell adhesion molecule 1) [NCBI Gene 5175] {aka CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM}, GPT (glutamic--pyruvic transaminase) [NCBI Gene 2875] {aka AAT1, ALT, ALT1, GPT1, SGPT}, mucin [NCBI Gene 100508689], ALK (ALK receptor tyrosine kinase) [NCBI Gene 238] {aka ALK1, CD246, NBLST3}, MUC16 (mucin 16, cell surface associated) [NCBI Gene 94025] {aka CA125}, SLC17A5 (solute carrier family 17 member 5) [NCBI Gene 26503] {aka AST, ISSD, NSD, SD, SIALIN, SIASD}
- **Diseases:** inflammation (MESH:D007249), bowel obstruction (MESH:D012778), hyperglycemia (MESH:D006943), epigastric pain (MESH:D010146), dysplasia (MESH:D015792), mucinous cystadenoma (MESH:D018291), mucinous cystadenocarcinoma (MESH:D018282), Acute Cholecystitis (MESH:D041881), cystic duct obstruction (MESH:D018297), gallstones (MESH:D042882), adenocarcinoma (MESH:D000230), Malignant (MESH:D009369), rupture (MESH:D012421), vascular lesion (MESH:D014652), metastatic disease (MESH:D000092182), neck mass (MESH:D006258), Hypodense hepatic lesion (MESH:C565408), nausea (MESH:D009325), jaundice (MESH:D007565), Cholecystitis (MESH:D002764), appendiceal mucinous neoplasms (MESH:D001063), diarrhea (MESH:D003967), fever (MESH:D005334), vomiting (MESH:D014839), AM (MESH:D009078), appendicitis (MESH:D001064), anemia (MESH:D000740), cavernous hemangioma (MESH:D006392), intussusception (MESH:D007443), hypertension (MESH:D006973), retention (MESH:D016055), pseudomyxoma peritonei (MESH:D011553), infection (MESH:D007239), Mucinous adenocarcinomas (MESH:D002288), chills (MESH:D023341), weight loss (MESH:D015431), leukocytosis (MESH:D007964), type 2 diabetes mellitus (MESH:D003924), thrombocytosis (MESH:D013922), perforation (MESH:D057112), hepatic lesion (MESH:D056486), drug allergies (MESH:D004342), constipation (MESH:D003248), cholelithiasis (MESH:D002769), hemangioma (MESH:D006391), Mucosal hyperplasias (MESH:D006965)
- **Chemicals:** metformin (MESH:D008687), lisinopril (MESH:D017706), iminodiacetic acid (MESH:C008109), glipizide (MESH:D005913), HIDA (MESH:C049470), morphine (MESH:D009020), alcohol (MESH:D000438)
- **Species:** Nicotiana tabacum (American tobacco, species) [taxon 4097], Homo sapiens (human, species) [taxon 9606]

## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12965301/full.md

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Source: https://tomesphere.com/paper/PMC12965301