# Emotional Dysregulation as a Mediator Between Childhood Adversity and Negative Urgency in Borderline Personality Disorder

**Authors:** Poojitha Konda Reddy, Kancharla Suresh Reddy, Gunde Surekha, Madhu Vamsi Ganduri, Kacham R Mohana, Azra Fatima, Nidhi R, Khande P Kumar, Amulya Arremsetty, Akhileshwar V Reddy

PMC · DOI: 10.7759/cureus.102953 · 2026-02-04

## TL;DR

This study shows that childhood adversity leads to impulsive behavior in borderline personality disorder through emotional dysregulation, in an Indian clinical sample.

## Contribution

Empirically validates emotional dysregulation as a mediator in the biosocial model of BPD in a non-Western context.

## Key findings

- Childhood adversity affects negative urgency through emotional dysregulation (indirect effect = 0.31).
- Emotional dysregulation fully mediates the relationship between childhood adversity and negative urgency.
- Findings support emotion regulation-focused therapies for BPD in an Indian population.

## Abstract

Background: The biosocial theory of borderline personality disorder (BPD) posits that emotional dysregulation develops from the transaction between a biological vulnerability and an invalidating environment (e.g., childhood adversity), and in turn leads to behavioral dyscontrol. This study aimed to empirically test this core mechanistic pathway in a non-Western clinical sample.

Methods: We hypothesized that the relationship between childhood adversity and the hallmark BPD trait of negative urgency (acting impulsively when distressed) would be mediated by difficulties in emotion regulation. A cross-sectional study was conducted with 45 adult patients with a Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) diagnosis of BPD in Hyderabad, India. Participants completed the Childhood Experience of Care and Abuse Questionnaire (CECA-Q), the Difficulties in Emotion Regulation Scale-Short Form (DERS-SF), and the Short UPPS-P (urgency, premeditation, perseverance, sensation seeking, and positive urgency) Impulsive Behaviour Scale. A bootstrapping-based mediation analysis (Hayes’ PROCESS Model 4) was used to test the hypothesized indirect effect.

Results: The analysis revealed a significant indirect effect of childhood adversity on negative urgency through emotional dysregulation (Indirect Effect = 0.31, 95% bootstrapped CI: 0.14, 0.52). The direct effect of childhood adversity on negative urgency, which was significant in the initial correlation, became non-significant (B = 0.08, p = 0.450) after accounting for the mediator. This pattern is consistent with full mediation.

Conclusion: This study provides strong, mechanism-based support for the biosocial model of BPD in an under-researched Indian context. The findings demonstrate that the pathogenic impact of childhood adversity on emotion-based impulsivity is explained by its disruption of emotion regulation capacities. This offers a clear empirical rationale for prioritizing emotion regulation-focused psychotherapies, such as dialectical behavior therapy, as the primary treatment approach for BPD.

## Linked entities

- **Diseases:** borderline personality disorder (MONDO:0001156)

## Full-text entities

- **Diseases:** adversity (MESH:D064420), sexual abuse (MESH:D000082002), ADHD (MESH:D001289), psychotic symptoms (MESH:D011618), intellectual disability (MESH:D008607), epilepsy (MESH:D004827), cognitive impairment (MESH:D003072), Impulsive Behavior (MESH:D010554), Impulsive (MESH:D007174), traumatic brain injury (MESH:D000070642), emotional abuse (MESH:D019966), Mental Disorders (MESH:D001523), physical abuse (MESH:D059445), schizophrenia spectrum disorder (MESH:D019967), BPD (MESH:D001883), injury (MESH:D014947), non (MESH:C580335), ERD (MESH:D051346), Dysregulation (MESH:D021081), distress (MESH:D012128), emotional abuse and neglect (MESH:D058069), NSSI (MESH:D012652)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12965186