# Ingredients for Success: What Clients and Informal Caregivers Value in Depression Treatment A Concept Mapping Study

**Authors:** Reine M. D. Ramaekers, Dyllis A. van Dijk, Marja Y. Veenstra, Koen R. J. Schruers, Suzanne C. van Bronswijk, Nicole K. Leibold

PMC · DOI: 10.1002/jclp.70092 · 2026-01-20

## TL;DR

This study explores what clients and caregivers consider important for successful depression treatment, identifying key factors like therapeutic alliance and treatment organization.

## Contribution

The study introduces a novel approach using concept mapping to integrate client and caregiver perspectives into understanding treatment success for depression.

## Key findings

- Participants identified 10 clusters of factors important for successful depression treatment.
- Therapeutic alliance was seen as more clinician-driven than client-driven.
- Treatment organization, elements, and guideline adherence formed a core concept for success.

## Abstract

Effective treatments are available for major depressive disorder; however, treatment efficacy is less pronounced in real‐life settings compared to research. One reason for this discrepancy may be that treatment outcomes assessed in research do not fully reflect domains important to treatment recipients: clients and their informal caregivers. Moreover, studies often struggle to assess the impact of process‐related factors on treatment success. More research incorporating client and informal caregiver perspectives is therefore needed to identify what they consider essential for a successful treatment.

Group Concept Mapping was employed to elicit insights from clients and informal caregivers regarding their experiences with depression treatment. Twenty‐one participants brainstormed in response to the statement: “Successful depression treatment requires…”. Subsequently, 32 participants sorted the identified factors into meaningful groups and rated their importance to treatment success.

Participants generated 79 unique responses in the brainstorm. They sorted these responses into 10 clusters: “The client”, “Treatment process”, “Treatment organisation”, “Interaction client clinician”, “The clinician”, “Clinician′s adherence to good practice”, “Drug treatment”, “Pre‐condition”, “Supporting activities”, and “Supportive work and home life”. Most clusters were considered important.

These findings support the idea of using multivariate and multimodal models for understanding treatment success. Participants attributed the therapeutic alliance as more clinician‐driven than client‐driven. A combination of factors related to treatment organization, treatment elements, and guideline adherence emerged as a core concept to successful treatment. Recommendations include increasing clinician awareness of perceptions of the therapeutic alliance and utilizing the findings to guide treatment discussions.

## Linked entities

- **Diseases:** depression (MONDO:0002050), major depressive disorder (MONDO:0002009)

## Full-text entities

- **Diseases:** Depression (MESH:D003866)

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12965048/full.md

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Source: https://tomesphere.com/paper/PMC12965048