# Bidirectional effects of physical activity and sleep on health: evidence and future directions

**Authors:** Vicente Javier Clemente-Suárez, Laura Redondo-Flórez, Ana Isabel Beltrán-Velasco, Domingo Jesús Ramos-Campo, Pablo Ruisoto, Rodrigo Yáñez-Sepúlveda, Alexandra Martín-Rodríguez, José Francisco Tornero-Aguilera

PMC · DOI: 10.3389/fspor.2026.1739588 · 2026-02-20

## TL;DR

This review explores how physical activity and sleep influence each other and overall health, emphasizing the need for future research using advanced technologies.

## Contribution

The paper highlights the bidirectional relationship between sleep and physical activity and suggests future research directions using wearable technology and personalized interventions.

## Key findings

- Regular physical activity improves sleep quality and duration.
- Adequate sleep enhances physical activity performance and recovery.
- Exercise interventions can mitigate the negative effects of sleep disorders on physical activity.

## Abstract

Sleep and physical activity are two important lifestyle factors that significantly influence overall health and wellbeing. This comprehensive review aims to provide a detailed understanding of the interplay between sleep and physical activity habits.

A narrative review was conducted through a comprehensive assessment of primary and secondary sources, incorporating scientific publications from databases such as MedLine, Cochrane, Embase, PsychINFO, and Cinahl. The inclusion criteria focused on studies published between 2000 and 2025, addressing topics such as physical activity, sleep quality, sleep disorders, energy balance, and related health outcomes. Exclusion criteria included gray literature, unpublished studies, books, conference proceedings, and dissertations.

The results highlight the complex bidirectional relationship between sleep and physical activity. Regular physical activity improves sleep quality and duration, while adequate sleep enhances physical activity performance and recovery. Sleep disorders negatively affect physical activity engagement, but interventions involving exercise demonstrate significant potential in mitigating these effects.

In conclusion, understanding the multifaceted interactions among sleep, physical activity, and nutrition is crucial for promoting overall health and wellbeing. Future research should leverage advancements in wearable technology, personalized interventions, and precision medicine approaches to optimize these interrelated behaviors and their health impacts.

## Full-text entities

- **Genes:** INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, MT1L (metallothionein 1L (pseudogene)) [NCBI Gene 4500] {aka MT1, MT1LP, MT1R, MTF}, IGF1 (insulin like growth factor 1) [NCBI Gene 3479] {aka IGF, IGF-I, IGFI, MGF}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}, MT2A (metallothionein 2A) [NCBI Gene 4502] {aka MT-2, MT-II, MT2}, IL10 (interleukin 10) [NCBI Gene 3586] {aka CSIF, GVHDS, IL-10, IL10A, TGIF}, GSR (glutathione-disulfide reductase) [NCBI Gene 2936] {aka CNSHA10, GR, GSRD, HEL-75, HEL-S-122m}, TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, MC4R (melanocortin 4 receptor) [NCBI Gene 4160] {aka BMIQ20}, GGH (gamma-glutamyl hydrolase) [NCBI Gene 8836] {aka GATD10, GH}, LEP (leptin) [NCBI Gene 3952] {aka LEPD, OB, OBS}, CXCR6 (C-X-C motif chemokine receptor 6) [NCBI Gene 10663] {aka BONZO, CD186, CDw186, STRL33, TYMSTR}, IL4 (interleukin 4) [NCBI Gene 3565] {aka BCGF-1, BCGF1, BSF-1, BSF1, IL-4}, GH1 (growth hormone 1) [NCBI Gene 2688] {aka GH, GH-N, GHB5, GHN, IGHD1A, IGHD1B}, IL13 (interleukin 13) [NCBI Gene 3596] {aka IL-13, P600}, BDNF (brain derived neurotrophic factor) [NCBI Gene 627] {aka ANON2, BULN2}, FTO (FTO alpha-ketoglutarate dependent dioxygenase) [NCBI Gene 79068] {aka ALKBH9, BMIQ14, GDFD, IFEX9}, ITGAM (integrin subunit alpha M) [NCBI Gene 3684] {aka CD11B, CR3A, HNA-4, MAC-1, MAC1A, MO1A}, SELL (selectin L) [NCBI Gene 6402] {aka CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL}, HCRT (hypocretin neuropeptide precursor) [NCBI Gene 3060] {aka NRCLP1, OX, PPOX}
- **Diseases:** shortness of breath (MESH:D004417), fibromyalgia (MESH:D005356), cardiovascular crises (MESH:D002318), hypoglycemia (MESH:D007003), Insomnia (MESH:D007319), mental illness (MESH:D001523), cancer (MESH:D009369), impaired decision-making skills (MESH:D020195), diabetes (MESH:D003920), Sleep disruption (MESH:D019958), prediabetic (MESH:D011236), insulin resistance (MESH:D007333), anxiety (MESH:D001007), asthma (MESH:D001249), Sleep cycle disturbances (MESH:D020178), inflammation (MESH:D007249), muscle damage (MESH:D009133), long-term illnesses (MESH:D000088562), injuries (MESH:D014947), metabolic syndrome (MESH:D024821), Micronutrient deficiencies (MESH:D007153), Sleep disorders (MESH:D012893), restless legs syndrome (MESH:D012148), major depressive disorder (MESH:D003865), SR (MESH:D002313), sleep apnea (MESH:D012891), cognitive impairment (MESH:D003072), infectious diseases (MESH:D003141), ANS (MESH:D001342), chronic disease (MESH:D002908), overtraining syndrome (MESH:D000095027), mood (MESH:D019964), Insufficient sleep (MESH:D012892), OSA (MESH:D020181), obese (MESH:D009765), depression (MESH:D003866), neurobehavioral deficits (MESH:D019954), diminished fine motor skills (MESH:D019957), fatigue (MESH:D005221), heart disease (MESH:D006331), stroke (MESH:D020521), overweight (MESH:D050177)
- **Chemicals:** omega-3 (MESH:D015525), amino acids (MESH:D000596), cortisol (MESH:D006854), starch (MESH:D013213), Saturated fatty acids (MESH:D005227), carbohydrate (MESH:D002241), adrenaline (MESH:D004837), Adenosine (MESH:D000241), Pilates (-), vitamin D (MESH:D014807), Melatonin (MESH:D008550), histamine (MESH:D006632), K (MESH:D011188), PUFAs (MESH:D005231), sugars (MESH:D000073893), Zn (MESH:D015032), caffeine (MESH:D002110), norepinephrine (MESH:D009638), GABA (MESH:D005680), glutamate (MESH:D018698), vitamin C (MESH:D001205), tryptophan (MESH:D014364), Cu (MESH:D003300), Mg (MESH:D008274), serotonin (MESH:D012701), purine nucleoside (MESH:D011684), Glucose (MESH:D005947), blood glucose (MESH:D001786), glycogen (MESH:D006003), Fe (MESH:D007501), testosterone (MESH:D013739), lipid (MESH:D008055), vitamin B12 (MESH:D014805), acetylcholine (MESH:D000109)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12964718/full.md

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Source: https://tomesphere.com/paper/PMC12964718