# A case of contrast-induced encephalopathy after thoracic endovascular aortic repair for a ruptured thoracic aortic aneurysm

**Authors:** Jumpei Tokutome, Yuichiro Kishimoto, Takeshi Onohara, Hiromu Horie, Tsuyoshi Sasami, Rikuto Nii, Naoki Sumi, Nozomi Kishimoto, Kenichi Morimoto, Junya Nakashima, Yasushi Yoshikawa

PMC · DOI: 10.1186/s44215-026-00244-7 · 2026-03-05

## TL;DR

A 79-year-old man developed contrast-induced encephalopathy after aortic repair surgery, highlighting the need for awareness of this rare complication.

## Contribution

Reports a novel case of CIE following thoracic endovascular aortic repair, expanding understanding of its occurrence beyond typical procedures.

## Key findings

- CIE occurred after 2-debranching TEVAR with 200 mL of contrast medium.
- Conservative management led to near-complete recovery within 9 days.
- CIE should be considered in delayed consciousness recovery after TEVAR in high-risk patients.

## Abstract

Contrast-Induced Encephalopathy (CIE) is a rare complication, most commonly reported after carotid or coronary interventions, possibly due to reporting bias.

We present a case of CIE following two-debranching thoracic endovascular aortic repair (TEVAR). A 79-year-old man with hypertension, hyperlipidemia, stage 4 chronic kidney disease (CKD), and prior cerebral infarction underwent emergency 2-debranching TEVAR for a ruptured thoracic aortic aneurysm (TAA). A total of 200 mL of contrast medium was used pre- and intraoperatively. On postoperative day (POD) 1, the patient remained unconscious despite sedation cessation. Non-contrast brain Computed tomography (CT) showed left hemispheric cerebral edema and high-density areas suggestive of contrast extravasation, raising suspicion for CIE. Conservative management with hydration and supportive care led to gradual recovery, with imaging on POD9 showing near-complete resolution.

Although rare, CIE should be considered in cases of delayed consciousness recovery after TEVAR, particularly in high-risk patients. Early diagnosis and conservative treatment are essential for good outcomes.

## Linked entities

- **Diseases:** hyperlipidemia (MONDO:0021187), chronic kidney disease (MONDO:0005300), cerebral infarction (MONDO:0002679), thoracic aortic aneurysm (MONDO:0005396)

## Full-text entities

- **Diseases:** CKD (MESH:D051436), edema (MESH:D004487), neurological complication (MESH:D002493), ischemic (MESH:D002545), rupture (MESH:D012421), neurotoxicity (MESH:D020258), ruptured thoracic aortic aneurysm (MESH:D001019), unconscious (MESH:D014474), occipital abnormalities (MESH:D006259), TAA (MESH:D017545), cerebral arterial disease (MESH:D002539), hyperlipidemia (MESH:D006949), cerebral complications (MESH:D008107), acute ischemic stroke (MESH:D000083242), stenosis of (MESH:D003251), neurological deficits (MESH:D009461), hypotension (MESH:D007022), stroke (MESH:D020521), hemorrhage (MESH:D006470), cerebral edema (MESH:D001929), CIE (MESH:D005119), cerebral infarction (MESH:D002544), TEVAR (MESH:D049914), MCA stenosis (MESH:D020244), encephalopathy (MESH:D001927), hypertension (MESH:D006973), ACA occlusion (MESH:D020243), Coma (MESH:D003128), infarct (MESH:D007238)
- **Chemicals:** propofol (MESH:D015742), iomeprol (MESH:C057937), ioversol (MESH:C054871), Expanded polytetrafluoroethylene (-), creatinine (MESH:D003404)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12964712/full.md

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Source: https://tomesphere.com/paper/PMC12964712