Pennisetum purpureum Schumach Supplementation Enhances Grip Strength in Adults with Low Muscle Mass: A Randomized Controlled Trial

TL;DR

A 12-week study found that taking Pennisetum purpureum Schumach improved grip strength in adults with low muscle mass, but had no significant effect on muscle mass or walking performance.

Contribution

This is the first randomized controlled trial to investigate Pennisetum purpureum Schumach's effects on muscle strength in adults with low muscle mass.

Findings

Pennisetum purpureum Schumach supplementation significantly increased grip strength after 8 and 12 weeks.

No significant changes in muscle mass or 10-meter walk test performance were observed.

Liver and kidney function remained unaffected by the supplementation.

Abstract

Low muscle mass and reduced muscle strength are prevalent among adults, particularly in the aging population, and are associated with an increased risk of sarcopenia-related complications. Pennisetum purpureum Schumach is a plant known for its antioxidant properties, but its effects on muscle strength and function in adults with low muscle mass remain unexplored. In this study, we investigated the effects of Pennisetum purpureum Schumach supplementation on liver and kidney function, hormonal markers, anthropometric measurements, and physical performance in adults with low muscle mass.

A 12-week randomized, double-blind, placebo-controlled trial was conducted with 35 participants with low muscle mass and reduced muscle strength. The experimental group received 300 mg of Pennisetum purpureum Schumach extract three times daily, while the placebo group received a placebo. Assessments included grip strength, muscle mass, liver and kidney function, and a 10-meter walk test at baseline, 8 weeks, and 12 weeks.

The experimental group showed a significant increase in grip strength (p < 0.05) after 8 and 12 weeks compared to baseline. No significant changes in muscle mass or performance in the 10-meter walk test were observed. Liver and kidney function remained unaffected in both groups.

Pennisetum purpureum Schumach supplementation was associated with an increase in grip strength after 8 and 12 weeks. No definitive effects were identified for muscle mass, walking performance, liver or kidney function, or hormonal markers. Observationally, some variability in testosterone levels was noted among male participants; however, the study lacked the design and statistical power necessary to determine hormonal effects. These findings suggest that the supplementation may be safe and potentially useful, although larger and parameter-comprehensive trials are required to verify physiological mechanisms and confirm efficacy.

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